Selected arylpiperazines are capable of reversing multidrug resistance in Escherichia coli overexpressing RND efflux pumps

被引：187

作者：

Bohnert, HA

Kern, WV ^{[1
]}

机构：

[1] Univ Freiburg, Med Klin, D-79106 Freiburg, Germany

[2] Univ Freiburg, Poliklin, D-79106 Freiburg, Germany

[3] Univ Hosp, Ctr Infect Dis & Travel Med, Dept Med, Freiburg, Germany

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 02期

关键词：

D O I：

10.1128/AAC.49.2.849-852.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Several arylpiperazines capable of reversing multidrug resistance (MDR) in Escherichia coli overexpressing acrAB and acrEF but not in pump-deficient mutant strains were identified. 1-(1-Naphthylmethyl)-piperazine, one of the more active compounds, enhanced susceptibility to fluoroquinolones and other agents and increased the intracellular concentration of levofloxacin and ethidium bromide, suggesting efflux pump inhibition as the mechanism of MDR reversal.

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收藏

页码：849 / 852

页数：4

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