Recent advances in crystal-induced acute inflammation

被引:63
作者
Akahoshi, Tohru
Murakami, Yousuke
Kitasato, Hidero
机构
[1] Kitasato Univ, Sch Med, Dept Gen Med, Sagamihara, Kanagawa 228, Japan
[2] Kitasato Univ, Sch Allied Hlth Sci, Dept Microbiol, Sagamihara, Kanagawa 228, Japan
[3] Kitasato Univ, Res Unit Clin Immunol, RIKEN, Res Ctr Allergy & Immunol, Sagamihara, Kanagawa 228, Japan
关键词
inflammasome; innate immunity; nuclear hormone receptors; Toll-like receptors; TREM-1;
D O I
10.1097/BOR.0b013e328014529a
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose of review The aim of this article is to highlight recent advances suggesting essential involvement of the innate immune system in crystal-induced acute inflammation. Recent findings Gout is a disease caused by the deposition of monosodium urate monohydrate crystals. Precise mechanisms underlying the initiation of monosodium urate monohydrate crystal-induced acute inflammation, however, are not known. Recent investigations provided novel evidence in the pathology of acute gout. Immunological study indicated that monosodium urate monohydrate crystals can act as a 'danger signal' that resembles exogenous adjuvants. Two laboratories have documented interesting findings that Toll-like receptor-mediated pathways or MyD88-dependent pathways are involved in monosodium urate monohydrate crystal-induced acute inflammation. Upregulation of the triggering receptor expressed on myeloid cells 1 (TREM-1) in phagocytes by the stimulation with monosodium urate monohydrate crystals has been demonstrated. Furthermore, pathological significance of NALP 3 inflammasome in gout has been shown. These findings provide a new concept that the innate immune system may play a crucial role on the triggering of crystal-induced acute inflammation. Spontaneous resolution is a characteristic feature of acute gout. Involvement of nuclear hormone receptors, peroxisome proliferator-activated receptor gamma and liver X receptor alpha, during the termination of acute gout has been also shown. Summary These studies provided a new insight into the mechanisms underlying the initiation and the termination of monosodium urate monohydrate crystal-induced acute inflammation.
引用
收藏
页码:146 / 150
页数:5
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