Immunogenicity and efficacy of alphavirus-derived replicon vaccines for respiratory syncytial virus and human metapneumovirus in nonhuman primates

被引：21

作者：

Bates, John T. ^{[1
]}

Pickens, Jennifer A. ^{[1
]}

Schuster, Jennifer E. ^{[2
]}

Johnson, Monika ^{[2
]}

Tollefson, Sharon J. ^{[2
]}

Williams, John V. ^{[2
,3
]}

Davis, Nancy L. ^{[5
]}

Johnston, Robert E. ^{[6
]}

Schultz-Darken, Nancy ^{[7
]}

Slaughter, James C. ^{[1
,4
]}

Smith-House, Frances ^{[1
]}

Crowe, James E., Jr. ^{[1
,2
,3
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Vanderbilt Vaccine Ctr, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Med Ctr, Nashville, TN 37232 USA

[3] Vanderbilt Univ, Med Ctr, Dept Pathol Microbiol & Immunol, Nashville, TN 37232 USA

[4] Vanderbilt Univ, Med Ctr, Dept Biostat, Nashville, TN 37232 USA

[5] Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA

[6] Global Vaccines, Durham, NC 27709 USA

[7] Univ Wisconsin, Wisconsin Natl Primate Res Ctr, Madison, WI 53715 USA

来源：

VACCINE | 2016年 / 34卷 / 07期

关键词：

Respiratory syncytial virus; Metapneumovirus; Vaccine; Replicon particles; Nonhuman primates; EQUINE ENCEPHALITIS-VIRUS; SURFACE GLYCOPROTEINS; COTTON RATS; INFECTION; FUSION; RSV; MUCOSAL; DISEASE; IMMUNIZATION; ENHANCEMENT;

D O I：

10.1016/j.vaccine.2015.12.045

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV) are major causes of illness among children, the elderly, and the immunocompromised. No vaccine has been licensed for protection against either of these viruses. We tested the ability of two Venezuelan equine encephalitis virus-based viral replicon particle (VEE-VRP) vaccines that express the hRSV or hMPV fusion (F) protein to confer protection against hRSV or hMPV in African green monkeys. Animals immunized with VEE-VRP vaccines developed RSV or MPV F-specific antibodies and serum neutralizing activity. Compared to control animals, immunized animals were better able to control viral load in the respiratory mucosa following challenge and had lower levels of viral genome in nasopharyngeal and bronchoalveolar lavage fluids. The high level of immunogenicity and protective efficacy induced by these vaccine candidates in nonhuman primates suggest that they hold promise for further development. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：950 / 956

页数：7

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