Wnt/β-catenin Signaling in Oral Tissue Development and Disease

被引：213

作者：

Liu, F. ^{[1
]}

Millar, S. E. ^{[2
,3
]}

机构：

[1] Texas A&M Hlth Sci Ctr, Scott & White Hosp, Inst Regenerat Med, Temple, TX 76502 USA

[2] Univ Penn, Sch Med, Dept Dermatol, Philadelphia, PA 19104 USA

[3] Univ Penn, Sch Med, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA

来源：

JOURNAL OF DENTAL RESEARCH | 2010年 / 89卷 / 04期

关键词：

Wnt; beta-catenin; development; tooth; taste; lip; oral tissue; cancer; NONSYNDROMIC CLEFT-LIP; EPITHELIAL-MESENCHYMAL INTERACTIONS; SUPERNUMERARY TOOTH FORMATION; SQUAMOUS-CELL CARCINOMAS; CRANIAL NEURAL CREST; BETA-CATENIN; GENE-EXPRESSION; E-CADHERIN; ADENOMATOUS POLYPOSIS; SONIC-HEDGEHOG;

D O I：

10.1177/0022034510363373

中图分类号：

R78 [口腔科学];

学科分类号：

100302 [口腔临床医学];

摘要：

The Wnt/beta-catenin signaling pathway is one of several key conserved intercellular signaling pathways in animals, and plays fundamental roles in the proliferation, regeneration, differentiation, and function of many cell and tissue types. This pathway is activated in a dynamic manner during the morphogenesis of oral organs, including teeth, taste papillae, and taste buds, and is essential for these processes to occur normally. Conversely, forced activation of Wnt/beta-catenin signaling promotes the formation of ectopic teeth and taste papillae. In this review, we discuss our current understanding of the roles of Wnt/beta-catenin signaling in oral tissue development and in related human diseases, and the potential of manipulating this pathway for therapeutic purposes.

引用

页码：318 / 330

页数：13

共 146 条

[1]

Mutation in WNT10A is associated with an autosomal recessive ectodermal dysplasia:: The odonto-onycho-dermal dysplasia [J].

Adaimy, Lynn ;

Chouery, Eliane ;

Megarbane, Hala ;

Mroueh, Salman ;

Delague, Valerie ;

Nicolas, Elsa ;

Belguith, Hanen ;

de Mazancourt, Philippe ;

Megarbane, Andre .

AMERICAN JOURNAL OF HUMAN GENETICS, 2007, 81 (04) :821-828

[2]

PITX2 and β-catenin interactions regulate lef-1 isoform expression [J].

Amen, Melanie ;

Liu, Xiaoming ;

Vadlamudi, Usha ;

Elizondo, Gabriela ;

Diamond, Evan ;

Engelhardt, John F. ;

Amendt, Brad A. .

MOLECULAR AND CELLULAR BIOLOGY, 2007, 27 (21) :7560-7573

[3]

EMBRYONIC ORIGIN OF AMPHIBIAN TASTE-BUDS [J].

BARLOW, LA ;

NORTHCUTT, RG .

DEVELOPMENTAL BIOLOGY, 1995, 169 (01) :273-285

[4]

Pontin52 and Reptin52 function as antagonistic regulators of β-catenin signalling activity [J].

Bauer, A ;

Chauvet, S ;

Huber, O ;

Usseglio, F ;

Rothbächer, U ;

Aragnol, D ;

Kemler, R ;

Pradel, J .

EMBO JOURNAL, 2000, 19 (22) :6121-6130

[5]

Bei M, 1998, DEVELOPMENT, V125, P4325

[6]

Follistatin modulates a BMP autoregulatory loop to control the size and patterning of sensory domains in the developing tongue [J].

Beites, Crestina L. ;

Hollenbeck, Piper L. W. ;

Kim, Joon ;

Lovell-Badge, Robin ;

Lander, Arthur D. ;

Calof, Anne L. .

DEVELOPMENT, 2009, 136 (13) :2187-2197

[7]

Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent [J].

Berndt, T ;

Craig, TA ;

Bowe, AE ;

Vassiliadis, J ;

Reczek, D ;

Finnegan, R ;

De Beur, SMJ ;

Schiavi, SC ;

Kumar, R .

JOURNAL OF CLINICAL INVESTIGATION, 2003, 112 (05) :785-794

[8]

Activation of β-catenin in prostate epithelium induces hyperplasias and squamous transdifferentiation [J].

Bierie, B ;

Nozawa, M ;

Renou, JP ;

Shillingford, JM ;

Morgan, F ;

Oka, T ;

Taketo, MM ;

Cardiff, RD ;

Miyoshi, K ;

Wagner, KU ;

Robinson, GW ;

Hennighausen, L .

ONCOGENE, 2003, 22 (25) :3875-3887

[9]

Association of chromosomal regions 3p21.2, 10p13, and 16p13.3 with nonsyndromic cleft lip and palate [J].

Blanton, SH ;

Bertin, T ;

Serna, ME ;

Stal, S ;

Mulliken, JB ;

Hecht, JT .

AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 2004, 125A (01) :23-27

[10]

WNT10A Mutations Are a Frequent Cause of a Broad Spectrum of Ectodermal Dysplasias with Sex-Biased Manifestation Pattern in Heterozygotes [J].

Bohring, Axel ;

Stamm, Thomas ;

Spaich, Christiane ;

Haase, Claudia ;

Spree, Kerstin ;

Hehr, Ute ;

Hoffmann, Mandy ;

Ledig, Susanne ;

Sel, Saadettin ;

Wieacker, Peter ;

Roepke, Albrecht .

AMERICAN JOURNAL OF HUMAN GENETICS, 2009, 85 (01) :97-105

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