Ascorbate oxidation is a prerequisite for its transport into rat liver microsomal vesicles

被引：27

作者：

Csala, M

Mile, V

Benedetti, A

Mandl, J

Bánhegyi, G

机构：

[1] Semmelweis Univ, Dept Med Chem, H-1444 Budapest, Hungary

[2] Univ Siena, Dipartimento Fisiopatol & Med Sperimentale, I-53100 Siena, Italy

来源：

BIOCHEMICAL JOURNAL | 2000年 / 349卷

关键词：

dehydroascorbate; endoplasmic recticulum; protein disulphide;

D O I：

10.1042/0264-6021:3490413

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Oxidation and uptake of ascorbate show similar time courses in rat liver microsomal vesicles: a rapid burst phase is followed by a slower process. Inhibitors of ascorbate oxidation (proadifen. econazole or quercetin) also effectively decreased the uptake of ascorbate, The results show that dehydroascorbate is the transport form of ascorbate at the membrane of the endoplasmic reticulum.

引用

收藏

页码：413 / 415

页数：3

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