Regulation of Interleukin-10 Gene Expression in Macrophages Engulfing Apoptotic Cells

被引：31

作者：

Zhang, Yan ^{[1
]}

Kim, Ha-Jeong ^{[1
]}

Yamamoto, Soichiro ^{[1
]}

Kang, Xiaoyan ^{[1
]}

Ma, Xiaojing ^{[1
,2
,3
]}

机构：

[1] Cornell Univ, Weill Med Coll, Dept Microbiol & Immunol, New York, NY 10065 USA

[2] Cornell Univ, Weill Med Coll, Dept Pediat, New York, NY 10065 USA

[3] Cornell Univ, Weill Grad Sch Med Sci, Program Immunol & Microbial Pathogenesis, New York, NY 10065 USA

来源：

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH | 2010年 / 30卷 / 03期

关键词：

SINGLE-NUCLEOTIDE POLYMORPHISMS; SYSTEMIC-LUPUS-ERYTHEMATOSUS; TUMOR-NECROSIS-FACTOR; ARREST-SPECIFIC GENE; POLY(ADP-RIBOSE) POLYMERASE; IL-10; PROMOTER; CYTOKINE PRODUCTION; INFLAMMATORY RESPONSE; RECEPTOR ANTAGONIST; AUTOANTIBODY LEVELS;

D O I：

10.1089/jir.2010.0004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Apoptosis and the rapid clearance of apoptotic cells (ACs) by professional or nonprofessional phagocytes are normal and coordinated processes that ensure controlled cell growth and stress response with nonpathological outcomes. Uptake of ACs by phagocytes is thought to suppress autoimmune responses through the release of anti-inflammatory cytokines such as interleukin-10 (IL-10), transforming growth factor-beta (TGF-beta), and inhibition of proinflammatory cytokines. The production of pro-and anti-inflammatory cytokines by phagocytes is highly regulated as part of an intrinsic mechanism to prevent inflammatory and autoimmune reactions in a physiological state. Production of IL-10 by phagocytes during clearance of ACs is critical to ensuring cellular homeostasis and suppression of autoimmunity. The molecular mechanism whereby IL-10 production is induced by ACs is only beginning to be understood. This review summarizes our recent work in this aspect of an essential physiological and homeostatic process.

引用

页码：113 / 121

页数：9

共 126 条

[1] Modulation of transcription by PARP-1:: Consequences in carcinogenesis and inflammation [J].

Aguilar-Quesada, R. ;

Munoz-Gamez, J. A. ;

Martin-Oliva, D. ;

Peralta-Leal, A. ;

Quiles-Perez, R. ;

Rodriguez-Vargas, J. M. ;

de Almodovar, M. Ruiz ;

Conde, C. ;

Ruiz-Extremera, A. ;

Oliver, F. J. .

CURRENT MEDICINAL CHEMISTRY, 2007, 14 (11) :1179-1187

[2] Activation of Reg gene, a gene for insulin-producing β-cell regeneration:: Poly(ADP-ribose) polymerase binds Reg promoter and regulates the transcription by autopoly(ADP-ribosyl)ation [J].

Akiyama, T ;

Takasawa, S ;

Nata, K ;

Kobayashi, S ;

Abe, M ;

Shervani, NJ ;

Ikeda, T ;

Nakagawa, K ;

Unno, M ;

Matsuno, S ;

Okamoto, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (01) :48-53

[3] Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling [J].

Alizadeh, AA ;

Eisen, MB ;

Davis, RE ;

Ma, C ;

Lossos, IS ;

Rosenwald, A ;

Boldrick, JG ;

Sabet, H ;

Tran, T ;

Yu, X ;

Powell, JI ;

Yang, LM ;

Marti, GE ;

Moore, T ;

Hudson, J ;

Lu, LS ;

Lewis, DB ;

Tibshirani, R ;

Sherlock, G ;

Chan, WC ;

Greiner, TC ;

Weisenburger, DD ;

Armitage, JO ;

Warnke, R ;

Levy, R ;

Wilson, W ;

Grever, MR ;

Byrd, JC ;

Botstein, D ;

Brown, PO ;

Staudt, LM .

NATURE, 2000, 403 (6769) :503-511

[4] Poly-(ADP-ribose) polymerase-1 (Parp-1) binds in a sequence-specific manner at the Bcl-6 locus and contributes to the regulation of Bcl-6 transcription [J].

Ambrose, H. E. ;

Papadopoulou, V. ;

Beswick, R. W. ;

Wagner, S. D. .

ONCOGENE, 2007, 26 (42) :6244-6252

[5] Relative production of tumour necrosis factor a and interleukin 10 in adult respiratory distress syndrome [J].

Armstrong, L ;

Millar, AB .

THORAX, 1997, 52 (05) :442-446

[6] Immune clearance of phosphatidylserine-expressing cells by phagocytes -: The role of β2-glycoprotein I in macrophage recognition [J].

Balasubramanian, K ;

Chandra, J ;

Schroit, AJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (49) :31113-31117

[7]

Baumann I, 2002, ARTHRITIS RHEUM-US, V46, P191, DOI 10.1002/1529-0131(200201)46:1<191::AID-ART10027>3.0.CO

[8]

2-K

[9] Role of Stat3 in lipopolysaccharide-induced IL-10 gene expression [J].

Benkhart, EM ;

Siedlar, M ;

Wedel, A ;

Werner, T ;

Ziegler-Heitbrock, HWL .

JOURNAL OF IMMUNOLOGY, 2000, 165 (03) :1612-1617

[10] Serum amyloid P component controls chromatin degradation and prevents antinuclear autoimmunity [J].

Bickerstaff, MCM ;

Botto, M ;

Hutchinson, WL ;

Herbert, J ;

Tennent, GA ;

Bybee, A ;

Mitchell, DA ;

Cook, HT ;

Butler, PJG ;

Walport, MJ ;

Pepys, MB .

NATURE MEDICINE, 1999, 5 (06) :694-697

← 1 2 3 4 5 6 7 8 9 10 →