Conserved synteny between the chicken Z sex chromosome and human chromosome 9 includes the male regulatory gene DMRT1:: a comparative (re)view on avian sex determination

被引：150

作者：

Nanda, I

Zend-Ajusch, E

Shan, Z

Grützner, F

Schartl, M

Burt, DW

Koehler, M

Fowler, VM

Goodwin, G

Schneider, WJ

Mizuno, S

Dechant, G

Haaf, T

Schmid, M

机构：

[1] Univ Wurzburg, Dept Human Genet, Biozentrum, D-97074 Wurzburg, Germany

[2] Max Planck Inst Mol Genet, Berlin, Germany

[3] Univ Wurzburg, Bioctr, Dept Physiol Chem 1, Wurzburg, Germany

[4] Roslin Inst, Roslin EH25 9PS, Midlothian, Scotland

[5] Scripps Res Inst, Dept Cell Biol, La Jolla, CA USA

[6] Haddow Labs, Inst Canc Res, Surrey, England

[7] Univ Vienna, Bioctr, Dept Mol Genet, Vienna, Austria

[8] Tohoku Univ, Dept Appl Biol Chem, Sendai, Miyagi 980, Japan

[9] Max Planck Inst Psychiat, D-8033 Martinsried, Germany

来源：

CYTOGENETICS AND CELL GENETICS | 2000年 / 89卷 / 1-2期

关键词：

D O I：

10.1159/000015567

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Sex-determination mechanisms in birds and mammals evolved independently for more than 300 million years. Unlike mammals, sex determination in birds operates through a ZZ/ZW sex chromosome system, in which the female is the heterogametic sex. However, the molecular mechanism remains to be elucidated. Comparative gene mapping revealed that several genes on human chromosome 9 (HSA 9) have homologs on the chicken Z chromosome (GGA Z), indicating the common ancestry of large parts of GGA Z and HSA 9. Based on chromosome homology maps, we isolated a Z-linked chicken ortholog of DMRT1, which has been implicated in XY sex reversal in humans. Its location on the avian Z and within the sex-reversal region on HSA 9p suggests that DMRT1 represents an ancestral dosage-sensitive gene for vertebrate sex-determination. Z dosage may be crucial for male sexual differentiation/determination in birds. Copyright (C) 2000 S. Karger AG. Basel.

引用

页码：67 / 78

页数：12

共 68 条

[1] Development of a chicken Z-chromosome-specific DNA library [J].

Ambady, S ;

Ciufo, S ;

Robl, JM ;

Smyth, JR ;

deLeon, FAP .

JOURNAL OF HEREDITY, 1997, 88 (03) :247-249

[2] Comparative genome organization of vertebrates [J].

Andersson, L ;

Archibald, A ;

Ashburner, M ;

Audun, S ;

Barendse, W ;

Bitgood, J ;

Bottema, C ;

Broad, T ;

Brown, S ;

Burt, D ;

Charlier, C ;

Copeland, N ;

Davis, S ;

Davisson, M ;

Edwards, J ;

Eggen, A ;

Elgar, G ;

Eppig, JT ;

Franklin, I ;

Grewe, P ;

Gill, T ;

Graves, JAM ;

Hawken, R ;

Hetzel, J ;

Hilyard, A ;

Jacob, H ;

Jaswinska, L ;

Jenkins, N ;

Kunz, H ;

Levan, G ;

Lie, O ;

Lyons, L ;

Maccarone, P ;

Mellersh, C ;

Montgomery, G ;

Moore, S ;

Moran, C ;

Morizot, D ;

Neff, M ;

Nicholas, F ;

OBrien, S ;

Parsons, Y ;

Peters, J ;

Postlethwait, J ;

Raymond, M ;

Rothschild, M ;

Schook, L ;

Sugimoto, Y ;

Szpirer, C ;

Tate, M .

MAMMALIAN GENOME, 1996, 7 (10) :717-734

[3] A DOSAGE SENSITIVE LOCUS AT CHROMOSOME XP21 IS INVOLVED IN MALE TO FEMALE SEX REVERSAL [J].

BARDONI, B ;

ZANARIA, E ;

GUIOLI, S ;

FLORIDIA, G ;

WORLEY, KC ;

TONINI, G ;

FERRANTE, E ;

CHIUMELLO, G ;

MCCABE, ERB ;

FRACCARO, M ;

ZUFFARDI, O ;

CAMERINO, G .

NATURE GENETICS, 1994, 7 (04) :497-501

[4] A SEX-LINKED ENZYME IN BIRDS - Z-CHROMOSOME CONSERVATION BUT NO DOSAGE COMPENSATION [J].

BAVERSTOCK, PR ;

ADAMS, M ;

POLKINGHORNE, RW ;

GELDER, M .

NATURE, 1982, 296 (5859) :763-766

[5]

BITGOOD JJ, 1993, MANIPULATION OF THE AVIAN GENOME, P61

[6]

Bridges CB, 1916, GENETICS, V1, P1

[7] MUTANT OOCYTIC LOW-DENSITY-LIPOPROTEIN RECEPTOR GENE FAMILY MEMBER CAUSES ATHEROSCLEROSIS AND FEMALE STERILITY [J].

BUJO, H ;

YAMAMOTO, T ;

HAYASHI, K ;

HERMANN, M ;

NIMPF, J ;

SCHNEIDER, WJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (21) :9905-9909

[8] CHICKEN OOCYTE GROWTH IS MEDIATED BY AN 8 LIGAND-BINDING REPEAT MEMBER OF THE LDL RECEPTOR FAMILY [J].

BUJO, H ;

HERMANN, M ;

KADERLI, MO ;

JACOBSEN, L ;

SUGAWARA, S ;

NIMPF, J ;

YAMAMOTO, T ;

SCHNEIDER, WJ .

EMBO JOURNAL, 1994, 13 (21) :5165-5175

[9]

Bull J., 1983, EVOLUTION SEX DETERM

[10] The dynamics of chromosome evolution in birds and mammals [J].

Burt, DW ;

Bruley, C ;

Dunn, IC ;

Jones, CT ;

Ramage, A ;

Law, AS ;

Morrice, DR ;

Paton, IR ;

Smith, J ;

Windsor, D ;

Sazanov, A ;

Fries, R ;

Waddington, D .

NATURE, 1999, 402 (6760) :411-413

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