Large Relaxivity Enhancement of Paramagnetic Lipid Nanoparticles by Restricting the Local Motions of the GdIII Chelates

被引：131

作者：

Kielar, Filip ^{[1
]}

Tei, Lorenzo ^{[1
]}

Terreno, Enzo ^{[2
,3
]}

Botta, Mauro ^{[1
]}

机构：

[1] Univ Piemonte Orientale Amedeo Avogadro, Dipartimento Sci Ambiente & Vita, Alessandria, Italy

[2] Univ Turin, Dept Chem IFM, Turin, Italy

[3] Univ Turin, Mol Imaging Ctr, Turin, Italy

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 23期

关键词：

MRI CONTRAST AGENTS; WATER EXCHANGE; COMPLEXES; INTERPLAY; ROTATION;

D O I：

10.1021/ja101518v

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A Gd-III-DOTA-like complex bearing two aliphatic chains on adjacent acetic arms was designed, synthesized, and compared with its analogous monofunctionalized complex. A 1/T-1 NMR relaxometric study of the two amphiphilic complexes incorporated into micelles and liposomes showed an unprecedented relaxivity enhancement for the complex with two lipophilic side arms. This remarkable result, which is attributed to a favorable water exchange rate and increased rigidity of the system resulting from limiting of the local motion of the gadolinium center, represents an important advance in the development of highly efficient nanosystems for MRI applications.

引用

页码：7836 / +

页数：3

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