On-resin peptide macrocyclization using thiol-ene click chemistry

被引：78

作者：

Aimetti, Alex A. ^{[1
]}

Shoemaker, Richard K. ^{[2
]}

Lin, Chien-Chi ^{[3
]}

Anseth, Kristi S. ^{[1
,3
]}

机构：

[1] Univ Colorado, Dept Chem & Biol Engn, Boulder, CO 80309 USA

[2] Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA

[3] Univ Colorado, Howard Hughes Med Inst, Boulder, CO 80309 USA

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 23期

关键词：

CYCLIC-PEPTIDES; BACKBONE CYCLIZATION; ANALOGS; PHOTOPOLYMERIZATION; TOOL;

D O I：

10.1039/c001375g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A versatile and rapid synthetic strategy has been developed for the on-resin cyclization of peptides using thiol-ene photochemistry. This unique method exploits the thiol group of natural cysteine amino acids and allows for various alkenes to be incorporated orthogonal to the peptide backbone.

引用

页码：4061 / 4063

页数：3

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