The multi-step nature of carcinogenesis and the implications for risk analysis

被引:13
作者
Cox, R [1 ]
机构
[1] Natl Radiol Protect Board, Didcot OX11 0RQ, Oxon, England
关键词
D O I
10.1080/095530098142194
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Purpose: For the purposes of constructing biologically realistic models of radiation cancer risk it is necessary to have detailed knowledge of the post-irradiation mechanisms involved. Methods: This brief review considers selected aspects of DNA damage response, tumour initiation/development, together with attendant factors and provides comment on the implications for cancer risk estimation and some of the uncertainties that remain. Conclusions: It is judged from studies with animal models that, in the main, radiation tumorigenesis proceeds in a conventional multi-step fashion following radiation-induced specific gene losses from single-target stem cells.
引用
收藏
页码:373 / 376
页数:4
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