Synthesis, Functionalization, and Biomedical Applications of Multifunctional Magnetic Nanoparticles

被引：1212

作者：

Hao, Rui ^{[1
]}

Xing, Ruijun ^{[1
]}

Xu, Zhichuan ^{[3
]}

Hou, Yanglong ^{[1
]}

Gao, Song ^{[2
]}

Sun, Shouheng ^{[3
]}

机构：

[1] Peking Univ, Dept Adv Mat & Nanotechnol, Coll Engn, Beijing 100871, Peoples R China

[2] Peking Univ, Beijing Natl Lab Mol Sci, State Key Lab Rare Earth Mat Chem & Applicat, Coll Chem & Mol Engn, Beijing 100871, Peoples R China

[3] Brown Univ, Dept Chem, Providence, RI 02912 USA

来源：

ADVANCED MATERIALS | 2010年 / 22卷 / 25期

关键词：

IRON-OXIDE NANOPARTICLES; POSITRON-EMISSION-TOMOGRAPHY; DRUG-DELIVERY; SUPERPARAMAGNETIC NANOPARTICLES; QUANTUM DOTS; MRI CONTRAST; FE3O4; NANOPARTICLES; CONTROLLED-RELEASE; GENE DELIVERY; HETEROSTRUCTURED NANOPARTICLES;

D O I：

10.1002/adma.201000260

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Synthesis of multifunctional magnetic nanoparticles (MFMNPs) is one of the most active research areas in advanced materials. MFMNPs that have magnetic properties and other functionalities have been demonstrated to show great promise as multimodality imaging probes. Their multifunctional surfaces also allow rational conjugations of biological and drug molecules, making it possible to achieve target-specific diagnostics and therapeutics. This review first outlines the synthesis of MNPs of metal oxides and alloys and then focuses on recent developments in the fabrication of MFMNPs of core/shell, dumbbell, and composite hybrid type. It also summarizes the general strategies applied for NP surface functionalization. The review further highlights some exciting examples of these MFMNPs for multimodality imaging and for target-specific drug/gene delivery applications.

引用

页码：2729 / 2742

页数：14

共 169 条

[1] Sonochemical synthesis of stable hydrosol of Fe3O4 nanoparticles [J].

Abu Mukh-Qasem, R ;

Gedanken, A .

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2005, 284 (02) :489-494

[2] Disposition of drugs in block copolymer micelle delivery systems - From discovery to recovery [J].

Aliabadi, Hamidreza Montazeri ;

Shahin, Mostafa ;

Brocks, Dion R. ;

Lavasanifar, Afsaneh .

CLINICAL PHARMACOKINETICS, 2008, 47 (10) :619-634

[3] Synthesis of Uniform Hollow Oxide Nanoparticles through Nanoscale Acid Etching [J].

An, Kwangjin ;

Kwon, Soon Gu ;

Park, Mihyun ;

Na, Hyon Bin ;

Baik, Sung-Il ;

Yu, Jung Ho ;

Kim, Dokyoon ;

Son, Jae Sung ;

Kim, Young Woon ;

Song, In Chan ;

Moon, Woo Kyung ;

Park, Hyun Min ;

Hyeon, Taeghwan .

NANO LETTERS, 2008, 8 (12) :4252-4258

[4] Evaluation of neck and body metastases to nodes with ferumoxtran 10-enhanced MR imaging: Phase III safety and efficacy study [J].

Anzai, Y ;

Piccoli, CW ;

Outwater, EK ;

Stanford, W ;

Bluemke, DA ;

Nurenberg, P ;

Saini, S ;

Maravilla, KR ;

Feldman, DE ;

Schmiedl, UP ;

Brunberg, JA ;

Francis, IR ;

Harms, SE ;

Som, PM ;

Tempany, CM .

RADIOLOGY, 2003, 228 (03) :777-788

[5] Electrospray of ionic precursor solutions to synthesize iron oxide nanoparticles: Modified scaling law [J].

Basak, Soubir ;

Chen, Da-Ren ;

Biswas, Pratim .

CHEMICAL ENGINEERING SCIENCE, 2007, 62 (04) :1263-1268

[6]

Beyer T, 2000, J NUCL MED, V41, P1369

[7] Versatile PEG-derivatized phosphine oxide ligands for water-dispersible metal oxide nanocrystals [J].

Bin Na, Hyon ;

Lee, In Su ;

Seo, Heonjin ;

Park, Yong Il ;

Lee, Jung Hee ;

Kim, Sang-Wook ;

Hyeon, Taeghwan .

CHEMICAL COMMUNICATIONS, 2007, (48) :5167-5169

[8] Superparamagnetic agents in magnetic resonance imaging: Physicochemical characteristics and clinical applications - A review [J].

Bonnemain, B .

JOURNAL OF DRUG TARGETING, 1998, 6 (03) :167-174

[9] Optical-based molecular imaging: contrast agents and potential medical applications [J].

Bremer, C ;

Ntziachristos, V ;

Weissleder, R .

EUROPEAN RADIOLOGY, 2003, 13 (02) :231-243

[10] Nanoparticles in cancer therapy and diagnosis [J].

Brigger, I ;

Dubernet, C ;

Couvreur, P .

ADVANCED DRUG DELIVERY REVIEWS, 2002, 54 (05) :631-651

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