Confirmation that a specific haplotype of the dopamine transporter gene is associated with combined-type ADHD

被引：100

作者：

Asherson, Philip ^{[1
]}

Brookes, Keeley

Franke, Barbara

Chen, Wai

Gill, Michael

Ebstein, Richard P.

Buitelaar, Jan

Banaschewski, Tobias

Sonuga-Barke, Edmund J. S.

Eisenberg, Jacques

Manor, Iris

Miranda, Ana

Oades, Robert D.

Roeyers, Herbert

Rothenberger, Aribert

Sergeant, Joseph

Steinhausen, Hans-Christoph

Faraone, Stephen V.

机构：

[1] Inst Psychiat, Social Genet Dev & Psychiat Ctr, London SE5 8AF, England

[2] Univ Clin Child & Adolescent Psychiat, Essen, Germany

[3] Mental Hlth Ctr, Petah Tiqwa, Israel

[4] Univ Gottingen, Dept Child & Adolescent Psychiat, Gottingen, Germany

[5] Univ Valencia, Dept Dev & Educ Psychol, Valencia, Spain

[6] Univ Southampton, Sch Psychol, Southampton, Hants, England

[7] Vrije Univ Amsterdam, Amsterdam, Netherlands

[8] ADHD Clin, Geha Mental Hlth Ctr, Petah Tiqwa, Israel

[9] S Herzog Mem Hosp, Jerusalem, Israel

[10] St James Hosp, Trinity Ctr Hlth Sci, Dept Psychiat, Dublin, Ireland

[11] Univ Ghent, B-9000 Ghent, Belgium

[12] Univ Zurich, Dept Child & Adolescent Psychiat, CH-8006 Zurich, Switzerland

[13] SUNY, Syracuse, NY USA

来源：

AMERICAN JOURNAL OF PSYCHIATRY | 2007年 / 164卷 / 04期

关键词：

DEFICIT HYPERACTIVITY DISORDER; SYSTEM GENES; LINKAGE; DAT1;

D O I：

10.1176/appi.ajp.164.4.674

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective: The primary purpose of this study was to confirm the association of a specific haplotype of the dopamine transporter gene and attention deficit hyperactivity disorder (ADHD), which could be one source of the heterogeneity seen across published studies. Method: The authors previously reported the association of ADHD with a subgroup of chromosomes containing specific alleles of two variable-number tandem repeat polymorphisms within the 3' untranslated region and intron 8 of the dopamine transporter gene. They now report on this association in a sample of ADHD combined-type probands. Results: The original observations were confirmed, with an overall odds ratio of 1.4 across samples. Conclusions: These data challenge results of meta-analyses suggesting that dopamine transporter variation does not have an effect on the risk for ADHD, and they indicate that further investigation of functional variation in the gene is required.

引用

页码：674 / 677

页数：4

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