Keeping track of pro-B cells: a new model for the effects of IL-7 during B cell development

被引：12

作者：

Monroe, JG ^{[1
]}

Allman, D ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2004年 / 34卷 / 10期

关键词：

IL-7; B cell; development;

D O I：

10.1002/eji.200425532

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Trophic and instructive models have been invoked to explain how various cytokines influence the survival, proliferation and differentiation of lymphoid progenitors. There is evidence that IL-7 can act in either a trophic or an instructive manner during B and T cell development although its roles in B cell development in the fetus versus the adult mouse and in the mouse versus the human may vary. Here we outline the stages of B cell development and the conventional model of the role of IL-7 in the transitions from pro-B cells to pre-B cells and then to immature B cells. We also discuss the implications of recent data that have led to a new model for this process.

引用

页码：2642 / 2646

页数：5

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