Highly satisfactory alkynylation of alkenyl halides via Pd-catalyzed cross-coupling with alkynylzincs and its critical comparison with the Sonogashira alkynylation
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Negishi, EI
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Purdue Univ, HC Brown & RB Wetherill Labs Chem, W Lafayette, IN 47907 USAPurdue Univ, HC Brown & RB Wetherill Labs Chem, W Lafayette, IN 47907 USA
Negishi, EI
[1
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Qian, MX
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Purdue Univ, HC Brown & RB Wetherill Labs Chem, W Lafayette, IN 47907 USAPurdue Univ, HC Brown & RB Wetherill Labs Chem, W Lafayette, IN 47907 USA
Qian, MX
[1
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Zeng, FX
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Purdue Univ, HC Brown & RB Wetherill Labs Chem, W Lafayette, IN 47907 USAPurdue Univ, HC Brown & RB Wetherill Labs Chem, W Lafayette, IN 47907 USA
Zeng, FX
[1
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Anastasia, L
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Babinski, D
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Purdue Univ, HC Brown & RB Wetherill Labs Chem, W Lafayette, IN 47907 USAPurdue Univ, HC Brown & RB Wetherill Labs Chem, W Lafayette, IN 47907 USA
Babinski, D
[1
]
机构:
[1] Purdue Univ, HC Brown & RB Wetherill Labs Chem, W Lafayette, IN 47907 USA
[GRAPHICS] The Pd-catalyzed alkynylation of various alkenyl halides and triflates with alkynylzincs proceeds well even with alkynyl derivatives containing electron-withdrawing groups. The reaction appears to be highly general. Noteworthy is that the corresponding Sonogashira reactions under various reported conditions are significantly less satisfactory in all cases performed in this study.