Highly satisfactory alkynylation of alkenyl halides via Pd-catalyzed cross-coupling with alkynylzincs and its critical comparison with the Sonogashira alkynylation

被引:86
作者
Negishi, EI [1 ]
Qian, MX [1 ]
Zeng, FX [1 ]
Anastasia, L [1 ]
Babinski, D [1 ]
机构
[1] Purdue Univ, HC Brown & RB Wetherill Labs Chem, W Lafayette, IN 47907 USA
关键词
D O I
10.1021/ol030010F
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
[GRAPHICS] The Pd-catalyzed alkynylation of various alkenyl halides and triflates with alkynylzincs proceeds well even with alkynyl derivatives containing electron-withdrawing groups. The reaction appears to be highly general. Noteworthy is that the corresponding Sonogashira reactions under various reported conditions are significantly less satisfactory in all cases performed in this study.
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页码:1597 / 1600
页数:4
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