Measurement of plasma procyanidin B-2 and procyanidin B-3 levels after oral administration in rat

被引：17

作者：

Tanaka, N

Sekiya, N

Hattori, M

Goto, H

Shibahara, N

Shimada, Y

Terasawa, K

机构：

[1] Toyama Med & Pharmaceut Univ, Fac Med, Dept Japanese Oriental Med, Toyama 9300194, Japan

[2] Toyama Med & Pharmaceut Univ, Inst Nat Med, Dept Metab Engn, Toyama 9300194, Japan

[3] Toyama Med & Pharmaceut Univ, Inst Nat Med, Dept Kampo Diagnost, Toyama 9300194, Japan

来源：

PHYTOMEDICINE | 2003年 / 10卷 / 2-3期

关键词：

procyanidin B-2; procyanidin B-3; fluorescence detection; ion spray mass spectrometry; Cinnamonomi cortex; oral absorption in rats;

D O I：

10.1078/094471103321659816

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Using a high-performance liquid chromatographic method and mass spectrometry analysis, we successfully measured the absorption of orally administered procyanidin B-2 and procyanidin B-3 isolated from Cinnamonomi cortex (the bark of Cinnamomum cassia Blume) in the rat plasma. This method used a TSK- GEL ODS-80TS column, two solvents (A: 0.01% acetic acid; B: methanol with 0.01% acetic acid) in a linear gradient at a flow-rate of 1.0 ml/min, and fluorescence detection at excitation and emission wavelengths of 220 and 327 nm.

引用

页码：122 / 126

页数：5

共 21 条

[1]

CASTEELE K V, 1983, Journal of Chromatography, V259, P291, DOI 10.1016/S0021-9673(01)88009-2

[2] ANTIHYPERTENSIVE PRINCIPLES FROM THE LEAVES OF MELASTOMA-CANDIDUM [J].