pH-sensitive freeze-dried chitosan-polyvinyl pyrrolidone hydrogels as controlled release system for antibiotic delivery

被引:389
作者
Risbud, MV
Hardikar, AA
Bhat, SV
Bhonde, RR [1 ]
机构
[1] Natl Ctr Cell sci, Tissue Engn & Tissue Banking Lab, Pune 411007, Maharashtra, India
[2] Indian Inst Technol, Sch Biomed Engn, Bombay 400076, Maharashtra, India
关键词
chitosan; polyvinyl pyrrolidone; hydrogel; controlled release; drug delivery;
D O I
10.1016/S0168-3659(00)00208-X
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The aim of this study was to develop a pH-sensitive chitosan/polyvinyl pyrrolidone (PVP) based controlled drug release system for antibiotic delivery. The hydrogels were synthesised by crosslinking chitosan and PVP blend with glutaraldehyde to form a semi-interpenetrating polymer network (semi-IPN). The semi-IPN formation was confirmed by Fourier transform infrared spectroscopic (FTIR) analysis. Semi-IPNs, viz, air-dried and freeze-dried, were compared for their surface morphology, wettability, swelling properties and pH-dependent swelling. Air- and freeze-dried membranes were also incorporated with amoxicillin and antibiotic release was studied. Porous freeze-dried hydrogels (pore diameter, 39.20+/-2.66 mu m) exhibited superior pH-dependent swelling properties over non-porous air-dried hydrogels. A high octane contact angle (144.20+/-0.580) of hydrogel was indicative of its hydrophilic nature. Increased swelling of hydrogels, under acidic conditions, was due to the protonation of a primary amino group on chitosan, as confirmed by FTIR analysis. Freeze-dried membranes released around 73% of the amoxicillin (33% by air-dried) in 3 h at pH 1.0 and, thus, had superior drug-release properties to air-dried hydrogels. Freeze-dried membranes could serve as potent candidates for antibiotic delivery in an acidic environment. (C) 2000 Published by Elsevier Science B.V. All rights reserved.
引用
收藏
页码:23 / 30
页数:8
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