HIV-1 subtype D infection is associated with faster disease progression than subtype A in spite of similar plasma HIV-1 loads

被引：199

作者：

Baeten, Jared M.

Chohan, Bhavna

Lavreys, Ludo

Chohan, Vrasha

McClelland, R. Scott

Certain, Laura

Mandaliya, Kishorchandra

Jaoko, Walter

Overbaugh, Julie

机构：

[1] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA

[2] Fred Hutchinson Canc Res Ctr, Div Human Biol, Seattle, WA 98109 USA

[3] Univ Washington, Dept Med, Seattle, WA 98195 USA

[4] Univ Washington, Dept Pathobiol, Seattle, WA 98195 USA

[5] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA

[6] Univ Washington, Med Sci Training Program, Seattle, WA 98195 USA

[7] Univ Nairobi, Dept Med Microbiol, Nairobi, Kenya

[8] Coast Provincial Gen Hosp, Mombasa, Kenya

来源：

JOURNAL OF INFECTIOUS DISEASES | 2007年 / 195卷 / 08期

关键词：

D O I：

10.1086/512682

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We investigated the effect of human immunodeficiency virus type 1 (HIV-1) subtype on disease progression among 145 Kenyan women followed from the time of HIV-1 acquisition. Compared with those infected with subtype A, women infected with subtype D had higher mortality ( hazard ratio, 2.3 [95% confidence interval, 1.0-5.6]) and a faster rate of CD4 cell count decline (P=.003). The mortality risk persisted after adjustment for plasma HIV-1 load. There were no differences in plasma viral load by HIV-1 subtype during follow-up. HIV-1 subtype D infection is associated with a 12-fold higher risk of death than subtype A infection, in spite of similar plasma HIV-1 loads.

引用

收藏

页码：1177 / 1180

页数：4

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