A number of tumor studies have indicated a link between CD4 help and the magnitude and persistence of CTL activity; however, the mechanisms underlying this have been largely unclear. To evaluate and determine the mechanisms by which CD4(+) T cells synergize,vith CD8(+) T cells to prevent tumor growth, we used the novel technique of monitoring in vivo CTL by labeling target cells with CFSE. This approach was supported by the direct visualization of CTL using peptide-MHC tetramers to follow tumor-specific T cells. The data presented demonstrate that while cotransfer of Ag-specific CD4(+) T cells was not required for the generation of CTLs, because adoptive transfer of CD8(+) T cells alone was sufficient, CD4(+) T cells were required for the maintenance of CD8(+) T cell numbers. Our data suggest that there is a correlation among the number of CD8(+) T cells, in vivo CTL function, and IFN-gamma production, with no evidence of a partial or nonresponsive phenotype among tetramer-positive cells. We also show that CD4(+) T cells are required for CD8(+) T cell infiltration of the tumor.
机构:PO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Immunol, Melbourne, Vic 3050, Australia
Bennett, SRM
Carbone, FR
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机构:
PO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Immunol, Melbourne, Vic 3050, AustraliaPO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Immunol, Melbourne, Vic 3050, Australia
Carbone, FR
Karamalis, F
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机构:PO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Immunol, Melbourne, Vic 3050, Australia
Karamalis, F
Flavell, RA
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h-index: 0
机构:PO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Immunol, Melbourne, Vic 3050, Australia
Flavell, RA
Miller, JFAP
论文数: 0引用数: 0
h-index: 0
机构:PO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Immunol, Melbourne, Vic 3050, Australia
Miller, JFAP
Heath, WR
论文数: 0引用数: 0
h-index: 0
机构:PO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Immunol, Melbourne, Vic 3050, Australia
机构:
UNIV WESTERN AUSTRALIA, QUEEN ELIZABETH II MED CTR, DEPT MED, NEDLANDS, WA, AUSTRALIAUNIV WESTERN AUSTRALIA, QUEEN ELIZABETH II MED CTR, DEPT MED, NEDLANDS, WA, AUSTRALIA
BIELEFELDTOHMANN, H
FITZPATRICK, DR
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h-index: 0
机构:
UNIV WESTERN AUSTRALIA, QUEEN ELIZABETH II MED CTR, DEPT MED, NEDLANDS, WA, AUSTRALIAUNIV WESTERN AUSTRALIA, QUEEN ELIZABETH II MED CTR, DEPT MED, NEDLANDS, WA, AUSTRALIA
FITZPATRICK, DR
MARZO, AL
论文数: 0引用数: 0
h-index: 0
机构:
UNIV WESTERN AUSTRALIA, QUEEN ELIZABETH II MED CTR, DEPT MED, NEDLANDS, WA, AUSTRALIAUNIV WESTERN AUSTRALIA, QUEEN ELIZABETH II MED CTR, DEPT MED, NEDLANDS, WA, AUSTRALIA
MARZO, AL
JARNICKI, AG
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h-index: 0
机构:
UNIV WESTERN AUSTRALIA, QUEEN ELIZABETH II MED CTR, DEPT MED, NEDLANDS, WA, AUSTRALIAUNIV WESTERN AUSTRALIA, QUEEN ELIZABETH II MED CTR, DEPT MED, NEDLANDS, WA, AUSTRALIA
JARNICKI, AG
HIMBECK, RP
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h-index: 0
机构:
UNIV WESTERN AUSTRALIA, QUEEN ELIZABETH II MED CTR, DEPT MED, NEDLANDS, WA, AUSTRALIAUNIV WESTERN AUSTRALIA, QUEEN ELIZABETH II MED CTR, DEPT MED, NEDLANDS, WA, AUSTRALIA
HIMBECK, RP
DAVIS, MR
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h-index: 0
机构:
UNIV WESTERN AUSTRALIA, QUEEN ELIZABETH II MED CTR, DEPT MED, NEDLANDS, WA, AUSTRALIAUNIV WESTERN AUSTRALIA, QUEEN ELIZABETH II MED CTR, DEPT MED, NEDLANDS, WA, AUSTRALIA
DAVIS, MR
MANNING, LS
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h-index: 0
机构:
UNIV WESTERN AUSTRALIA, QUEEN ELIZABETH II MED CTR, DEPT MED, NEDLANDS, WA, AUSTRALIAUNIV WESTERN AUSTRALIA, QUEEN ELIZABETH II MED CTR, DEPT MED, NEDLANDS, WA, AUSTRALIA
MANNING, LS
ROBINSON, BWS
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h-index: 0
机构:
UNIV WESTERN AUSTRALIA, QUEEN ELIZABETH II MED CTR, DEPT MED, NEDLANDS, WA, AUSTRALIAUNIV WESTERN AUSTRALIA, QUEEN ELIZABETH II MED CTR, DEPT MED, NEDLANDS, WA, AUSTRALIA
机构:UNIV WESTERN AUSTRALIA, QUEEN ELIZABETH II MED CTR, DEPT MED, 4TH FLOOR G BLOCK, NEDLANDS, WA 6009, AUSTRALIA
DAVIS, MR
MANNING, LS
论文数: 0引用数: 0
h-index: 0
机构:UNIV WESTERN AUSTRALIA, QUEEN ELIZABETH II MED CTR, DEPT MED, 4TH FLOOR G BLOCK, NEDLANDS, WA 6009, AUSTRALIA
MANNING, LS
WHITAKER, D
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h-index: 0
机构:UNIV WESTERN AUSTRALIA, QUEEN ELIZABETH II MED CTR, DEPT MED, 4TH FLOOR G BLOCK, NEDLANDS, WA 6009, AUSTRALIA
WHITAKER, D
GARLEPP, MJ
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h-index: 0
机构:UNIV WESTERN AUSTRALIA, QUEEN ELIZABETH II MED CTR, DEPT MED, 4TH FLOOR G BLOCK, NEDLANDS, WA 6009, AUSTRALIA
GARLEPP, MJ
ROBINSON, BWS
论文数: 0引用数: 0
h-index: 0
机构:
UNIV WESTERN AUSTRALIA, QUEEN ELIZABETH II MED CTR, DEPT MED, 4TH FLOOR G BLOCK, NEDLANDS, WA 6009, AUSTRALIAUNIV WESTERN AUSTRALIA, QUEEN ELIZABETH II MED CTR, DEPT MED, 4TH FLOOR G BLOCK, NEDLANDS, WA 6009, AUSTRALIA
机构:PO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Immunol, Melbourne, Vic 3050, Australia
Bennett, SRM
Carbone, FR
论文数: 0引用数: 0
h-index: 0
机构:
PO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Immunol, Melbourne, Vic 3050, AustraliaPO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Immunol, Melbourne, Vic 3050, Australia
Carbone, FR
Karamalis, F
论文数: 0引用数: 0
h-index: 0
机构:PO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Immunol, Melbourne, Vic 3050, Australia
Karamalis, F
Flavell, RA
论文数: 0引用数: 0
h-index: 0
机构:PO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Immunol, Melbourne, Vic 3050, Australia
Flavell, RA
Miller, JFAP
论文数: 0引用数: 0
h-index: 0
机构:PO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Immunol, Melbourne, Vic 3050, Australia
Miller, JFAP
Heath, WR
论文数: 0引用数: 0
h-index: 0
机构:PO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Immunol, Melbourne, Vic 3050, Australia
机构:
UNIV WESTERN AUSTRALIA, QUEEN ELIZABETH II MED CTR, DEPT MED, NEDLANDS, WA, AUSTRALIAUNIV WESTERN AUSTRALIA, QUEEN ELIZABETH II MED CTR, DEPT MED, NEDLANDS, WA, AUSTRALIA
BIELEFELDTOHMANN, H
FITZPATRICK, DR
论文数: 0引用数: 0
h-index: 0
机构:
UNIV WESTERN AUSTRALIA, QUEEN ELIZABETH II MED CTR, DEPT MED, NEDLANDS, WA, AUSTRALIAUNIV WESTERN AUSTRALIA, QUEEN ELIZABETH II MED CTR, DEPT MED, NEDLANDS, WA, AUSTRALIA
FITZPATRICK, DR
MARZO, AL
论文数: 0引用数: 0
h-index: 0
机构:
UNIV WESTERN AUSTRALIA, QUEEN ELIZABETH II MED CTR, DEPT MED, NEDLANDS, WA, AUSTRALIAUNIV WESTERN AUSTRALIA, QUEEN ELIZABETH II MED CTR, DEPT MED, NEDLANDS, WA, AUSTRALIA
MARZO, AL
JARNICKI, AG
论文数: 0引用数: 0
h-index: 0
机构:
UNIV WESTERN AUSTRALIA, QUEEN ELIZABETH II MED CTR, DEPT MED, NEDLANDS, WA, AUSTRALIAUNIV WESTERN AUSTRALIA, QUEEN ELIZABETH II MED CTR, DEPT MED, NEDLANDS, WA, AUSTRALIA
JARNICKI, AG
HIMBECK, RP
论文数: 0引用数: 0
h-index: 0
机构:
UNIV WESTERN AUSTRALIA, QUEEN ELIZABETH II MED CTR, DEPT MED, NEDLANDS, WA, AUSTRALIAUNIV WESTERN AUSTRALIA, QUEEN ELIZABETH II MED CTR, DEPT MED, NEDLANDS, WA, AUSTRALIA
HIMBECK, RP
DAVIS, MR
论文数: 0引用数: 0
h-index: 0
机构:
UNIV WESTERN AUSTRALIA, QUEEN ELIZABETH II MED CTR, DEPT MED, NEDLANDS, WA, AUSTRALIAUNIV WESTERN AUSTRALIA, QUEEN ELIZABETH II MED CTR, DEPT MED, NEDLANDS, WA, AUSTRALIA
DAVIS, MR
MANNING, LS
论文数: 0引用数: 0
h-index: 0
机构:
UNIV WESTERN AUSTRALIA, QUEEN ELIZABETH II MED CTR, DEPT MED, NEDLANDS, WA, AUSTRALIAUNIV WESTERN AUSTRALIA, QUEEN ELIZABETH II MED CTR, DEPT MED, NEDLANDS, WA, AUSTRALIA
MANNING, LS
ROBINSON, BWS
论文数: 0引用数: 0
h-index: 0
机构:
UNIV WESTERN AUSTRALIA, QUEEN ELIZABETH II MED CTR, DEPT MED, NEDLANDS, WA, AUSTRALIAUNIV WESTERN AUSTRALIA, QUEEN ELIZABETH II MED CTR, DEPT MED, NEDLANDS, WA, AUSTRALIA
机构:UNIV WESTERN AUSTRALIA, QUEEN ELIZABETH II MED CTR, DEPT MED, 4TH FLOOR G BLOCK, NEDLANDS, WA 6009, AUSTRALIA
DAVIS, MR
MANNING, LS
论文数: 0引用数: 0
h-index: 0
机构:UNIV WESTERN AUSTRALIA, QUEEN ELIZABETH II MED CTR, DEPT MED, 4TH FLOOR G BLOCK, NEDLANDS, WA 6009, AUSTRALIA
MANNING, LS
WHITAKER, D
论文数: 0引用数: 0
h-index: 0
机构:UNIV WESTERN AUSTRALIA, QUEEN ELIZABETH II MED CTR, DEPT MED, 4TH FLOOR G BLOCK, NEDLANDS, WA 6009, AUSTRALIA
WHITAKER, D
GARLEPP, MJ
论文数: 0引用数: 0
h-index: 0
机构:UNIV WESTERN AUSTRALIA, QUEEN ELIZABETH II MED CTR, DEPT MED, 4TH FLOOR G BLOCK, NEDLANDS, WA 6009, AUSTRALIA
GARLEPP, MJ
ROBINSON, BWS
论文数: 0引用数: 0
h-index: 0
机构:
UNIV WESTERN AUSTRALIA, QUEEN ELIZABETH II MED CTR, DEPT MED, 4TH FLOOR G BLOCK, NEDLANDS, WA 6009, AUSTRALIAUNIV WESTERN AUSTRALIA, QUEEN ELIZABETH II MED CTR, DEPT MED, 4TH FLOOR G BLOCK, NEDLANDS, WA 6009, AUSTRALIA