Resolving conflicting crystallographic and NMR models for solution-state DNA with solution X-ray diffraction

被引：31

作者：

Zuo, XB ^{[1
]}

Tiede, DM ^{[1
]}

机构：

[1] Argonne Natl Lab, Chem Div, Argonne, IL 60439 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 01期

关键词：

D O I：

10.1021/ja044533+

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report on synchrotron-based high-angle X-ray solution scattering measured to 2 Å resolution for two synthetic DNA sequences for which there are conflicting X-ray crystal and solution NMR models. Our results demonstrate that high-angle X-ray scattering discriminates between differing X-ray crystal and NMR models for solution-state DNA and provides a direct, independent method for testing structural models and measuring solution-state configurational dispersions. Copyright © 2005 American Chemical Society.

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页码：16 / 17

页数：2

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