Asymmetric electrophilic fluorination of α-cyanoalkylphosphonates catalyzed by chiral palladium complexes

被引：75

作者：

Kang, Young Ku ^{[1
]}

Cho, Min Je ^{[1
]}

Kim, Sun Mi ^{[1
]}

Kim, Dae Young ^{[1
]}

机构：

[1] Soonchunhyang Univ, Div Appl Sci, Dept Chem, Asan 336745, Chungnam, South Korea

来源：

SYNLETT | 2007年 / 07期

关键词：

electrophilic fluorination; asymmetric catalysis; chiral palladium catalysts; alpha-cyanoalkylphosphonates; alpha-fluoroalkylphosphonates;

D O I：

10.1055/s-2007-977436

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The catalytic enantioselective fluorination of alpha-cyanoalkylphosphonates catalyzed by chiral palladium complexes was examined. Treatment of alpha-cyanoalkylphosphonates with N-fluoro-benzenesulfonimide as the electrophilic fluorinating reagent under mild reaction conditions afforded the corresponding alpha-fluorinated alpha-cyanoalkylphosphonates in excellent yields with high enantiomeric excesses (80-91%).

引用

页码：1135 / 1138

页数：4

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