Megalin and cubilin, role in proximal tubule function and during development

被引：62

作者：

Christensen, EI

Verroust, PJ

机构：

[1] Aarhus Univ, Dept Cell Biol, Inst Anat, DK-8000 Aarhus C, Denmark

[2] CHU St Antoine, INSERM, U538, F-75012 Paris, France

来源：

PEDIATRIC NEPHROLOGY | 2002年 / 17卷 / 12期

关键词：

endocytosis; fetal development; yolk sac; vitamin D; vitamin B-12;

D O I：

10.1007/s00467-002-0956-5

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Epithelia lining the proximal convoluted epithelium and the visceral yolk sac in rodents are characterized by their ability to internalize and degrade many proteins facing their apical pole. It has become apparent over the last decade that this property is mediated through a very high endocytic activity and the expression of at least two distinct multiligand receptors, cubilin and megalin, characterized by the accumulation of ligandbinding units, LDL receptor class A repeats and CUB domains, respectively. We review here evidence that both receptors are involved in proximal tubule function and embryonic development.

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页码：993 / 999

页数：7

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