Positive and Negative Modulation of Angiogenesis by VEGFR1 Ligands

被引：225

作者：

Cao, Yihai ^{[1
]}

机构：

[1] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, S-17177 Stockholm, Sweden

来源：

SCIENCE SIGNALING | 2009年 / 2卷 / 59期

关键词：

ENDOTHELIAL-GROWTH-FACTOR; FACTOR GENE-EXPRESSION; INHIBITS TUMOR-GROWTH; HIGH-AFFINITY BINDING; TYROSINE-KINASE; FACTOR-B; FACTOR RECEPTOR-1; SIGNAL-TRANSDUCTION; FACTOR-I; VASCULAR-PERMEABILITY;

D O I：

10.1126/scisignal.259re1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Vascular endothelial growth factor-A (VEGF-A) is a key target for new antiangiogenic drugs for the treatment of both malignant and nonmalignant human diseases. Vascular effects of VEGF family members are mainly mediated by VEGF receptor 2 (VEGFR2). Conversely, the function and signaling of VEGFR1, which is present on endothelial and nonendothelial cells, are poorly understood. Intriguingly, two of five members in the VEGF family-VEGF-B and placental growth factor (PlGF)-are exclusive ligands for VEGFR1 and do not interact with the other VEGFRs, VEGFR2 and VEGFR3. These VEGFR1-specific ligands may be important therapeutic targets for the treatment of cancer. This Review discusses the distinctive roles of VEGFR1 and its ligands PlGF and VEGF-B in the mediation of angiogenic signaling and considers the therapeutic potential of targeting these particular vascular factors.

引用

页数：11

共 132 条

[41] Anti-PIGF inhibits growth of VEGF(R)-Inhibitor-Resistant tumors without affecting healthy vessels [J].

Fischer, Christian ;

Jonckx, Bart ;

Mazzone, Massimiliano ;

Zacchigna, Serena ;

Loges, Sonja ;

Pattarini, Lucia ;

Chorianopoulos, Emmanuel ;

Liesenborghs, Laurens ;

Koch, Marta ;

De Mol, Maria ;

Autiero, Monica ;

Wyns, Sabine ;

Plaisance, Stephane ;

Moons, Lieve ;

van Rooijen, Nico ;

Giacca, Mauro ;

Stassen, Jean-Marie ;

Dewerchin, Mieke ;

Collen, Desire ;

Carmeliet, Peter .

CELL, 2007, 131 (03) :463-475

[42] Is angiogenesis an organizing principle in biology and medicine? [J].

Folkman, Judah .

JOURNAL OF PEDIATRIC SURGERY, 2007, 42 (01) :1-11

[43] ROLE OF THE FLT-1 RECEPTOR TYROSINE KINASE IN REGULATING THE ASSEMBLY OF VASCULAR ENDOTHELIUM [J].

FONG, GH ;

ROSSANT, J ;

GERTSENSTEIN, M ;

BREITMAN, ML .

NATURE, 1995, 376 (6535) :66-70

[44] A phase I dose escalation and pharmacokinetic (PK) study of intravenous (iv) aflibercept (VEGF Trap) plus docetaxel (D) and cisplatin (C) in patients (pts) with advanced solid tumors: preliminary results [J].

Freyer, G., Sr. ;

Fumoleau, P. ;

You, B. ;

Isambert, N. ;

Chevalier, P. ;

Lenoir, V. Trillet .

JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (15)

[45] VEGF function for upregulation of endogenous PlGF expression during FGF-2-mediated therapeutic angiogenesis [J].

Fujii, Takaaki ;

Yonemitsu, Yoshikazu ;

Onimaru, Mitsuho ;

Inoue, Makoto ;

Hasegawa, Mamoru ;

Kuwano, Hiroyuki ;

Sueishi, Katsuo .

ATHEROSCLEROSIS, 2008, 200 (01) :51-57

[46] Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development [J].

Gale, NW ;

Dominguez, MG ;

Noguera, I ;

Pan, L ;

Hughes, V ;

Valenzuela, DM ;

Murphy, AJ ;

Adams, NC ;

Lin, HC ;

Holash, J ;

Thurston, G ;

Yancopoulos, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (45) :15949-15954

[47] DIPHENYLENE IODONIUM INHIBITS THE INDUCTION OF ERYTHROPOIETIN AND OTHER MAMMALIAN GENES BY HYPOXIA - IMPLICATIONS FOR THE MECHANISM OF OXYGEN SENSING [J].

GLEADLE, JM ;

EBERT, BL ;

RATCLIFFE, PJ .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1995, 234 (01) :92-99

[48] Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rate [J].

Goldman, CK ;

Kendall, RL ;

Cabrera, G ;

Soroceanu, L ;

Heike, Y ;

Gillespie, GY ;

Siegal, GP ;

Mao, XZ ;

Bett, AJ ;

Huckle, WR ;

Thomas, KA ;

Curiel, DT .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (15) :8795-8800

[49]

Green CJ, 2001, CANCER RES, V61, P2696

[50] Cloning and characterization of a novel human gene related to vascular endothelial growth factor [J].

Grimmond, S ;

Lagercrantz, J ;

Drinkwater, C ;

Silins, G ;

Townson, S ;

Pollock, P ;

Gotley, D ;

Carson, E ;

Rakar, S ;

Nordenskjold, M ;

Ward, L ;

Hayward, N ;

Weber, G .

GENOME RESEARCH, 1996, 6 (02) :124-131

← 1 2 3 4 5 6 7 8 9 10 →