Loss of connectivity in Alzheimer's disease: an evaluation of white matter tract integrity with colour coded MR diffusion tensor imaging

被引:365
作者
Rose, SE [1 ]
Chen, F
Chalk, JB
Zelaya, FO
Strugnell, WE
Benson, M
Semple, J
Doddrell, DM
机构
[1] Univ Queensland, Ctr Magnet Resonance, Brisbane, Qld 4072, Australia
[2] Princess Alexandra Hosp, Dept Med, Brisbane, Qld 4102, Australia
[3] Princess Alexandra Hosp, Dept Radiol, Brisbane, Qld 4102, Australia
[4] Inst Psychiat, London SE5 8AF, England
[5] Univ Cambridge, Acad Dept Psychiat, Addenbrookes Ctr Clin Invest, SmithKline Beecham Pharmaceut, Cambridge CB2 2GG, England
关键词
Alzheimer's disease; diffusion tensor MRI;
D O I
10.1136/jnnp.69.4.528
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
A novel MRI method-diffusion tensor imaging-was used to compare the integrity of several white matter fibre tracts in patients with probable Alzheimer's disease. Relative to normal controls, patients with probable Alzheimer's disease showed a highly significant reduction in the integrity of the association white matter fibre tracts, such as the splenium of the corpus callosum, superior longitudinal fasciculus, and cingulum. By contrast, pyramidal tract integrity seemed unchanged. This novel finding is consistent with the clinical presentation of probable Alzheimer's disease, in which global cognitive decline is a more prominent feature than motor disturbance.
引用
收藏
页码:528 / 530
页数:3
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