Setting the tone: superficial dorsal horn projection neurons regulate pain sensitivity

被引：53

作者：

Mantyh, PW ^{[1
]}

Hunt, SP

机构：

[1] Univ Minnesota, Neurosyst Ctr, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Ctr Canc, Minneapolis, MN 55455 USA

[3] Univ Minnesota, Dep Prevent Sci, Minneapolis, MN 55455 USA

[4] Univ Minnesota, Dept Psychiat, Minneapolis, MN 55455 USA

[5] Univ Minnesota, Dept Neurosci, Minneapolis, MN 55455 USA

[6] VA Med Ctr, Minneapolis, MN 55417 USA

[7] UCL, Dept Anat & Dev Biol, London WC1E 6BT, England

来源：

TRENDS IN NEUROSCIENCES | 2004年 / 27卷 / 10期

关键词：

D O I：

10.1016/j.tins.2004.07.007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The neurokinin-1 receptor is expressed by lamina I projection neurons of the spinal cord that are crucial for regulating pain behavior. These neurons are nocispecific, support long-term potentiation and appear to downregulate the K(+)-Cl(-) exporter channel KCC2 following peripheral nerve damage, leading to increased excitability. These lamina I neurons project to the brainstem and thalamus and modulate descending inhibitory and excitatory pathways to the dorsal horn that regulate nociceptive traffic.

引用

页码：582 / 584

页数：3

共 21 条

[1] Physiological properties of the lamina I spinoparabrachial neurons in the rat [J].

Bester, H ;

Chapman, V ;

Besson, JM ;

Bernard, JF .

JOURNAL OF NEUROPHYSIOLOGY, 2000, 83 (04) :2239-2259

[2] Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain [J].

Coull, JAM ;

Boudreau, D ;

Bachand, K ;

Prescott, SA ;

Nault, F ;

Sik, A ;

De Koninck, P ;

De Koninck, Y .

NATURE, 2003, 424 (6951) :938-942

[3] CUTANEOUS STIMULI RELEASING IMMUNOREACTIVE SUBSTANCE-P IN THE DORSAL HORN OF THE CAT [J].

DUGGAN, AW ;

HENDRY, IA ;

MORTON, CR ;

HUTCHISON, WD ;

ZHAO, ZQ .

BRAIN RESEARCH, 1988, 451 (1-2) :261-273

[4] Posterior triangular thalamic neurons convey nociceptive messages to the secondary somatosensory and insular cortices in the rat [J].

Gauriau, C ;

Bernard, JF .

JOURNAL OF NEUROSCIENCE, 2004, 24 (03) :752-761

[5] A comparative reappraisal of projections from the superficial laminae of the dorsal horn in the rat: The forebrain [J].

Gauriau, C ;

Bernard, JF .

JOURNAL OF COMPARATIVE NEUROLOGY, 2004, 468 (01) :24-56

[6] IMMUNOHISTOCHEMICAL ANALYSIS OF PEPTIDE PATHWAYS POSSIBLY RELATED TO PAIN AND ANALGESIA - ENKEPHALIN AND SUBSTANCE-P [J].

HOKFELT, T ;

LJUNGDAHL, A ;

TERENIUS, L ;

ELDE, R ;

NILSSON, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (07) :3081-3085

[7] The molecular dynamics of pain control [J].

Hunt, SP ;

Mantyh, PW .

NATURE REVIEWS NEUROSCIENCE, 2001, 2 (02) :83-91

[8] VR1-positive primary afferents contact NK1-positive spinoparabrachial neurons [J].

Hwang, SJ ;

Burette, A ;

Valtschanoff, JG .

JOURNAL OF COMPARATIVE NEUROLOGY, 2003, 460 (02) :255-265

[9] Synaptic plasticity in spinal lamina I projection neurons that mediate hyperalgesia [J].

Ikeda, H ;

Heinke, B ;

Ruscheweyh, R ;

Sandkühler, J .

SCIENCE, 2003, 299 (5610) :1237-1240

[10] Analgesia and hyperalgesia from GABA-mediated modulation of the cerebral cortex [J].

Jasmin, L ;

Rabkin, SD ;

Granato, A ;

Boudah, A ;

Ohara, PT .

NATURE, 2003, 424 (6946) :316-320

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