Birth and adaptive evolution of a hominoid gene that supports high neurotransmitter flux

被引：154

作者：

Burki, F ^{[1
]}

Kaessmann, H ^{[1
]}

机构：

[1] Univ Lausanne, Ctr Integrat Genom, BEP, CH-1015 Lausanne, Switzerland

来源：

NATURE GENETICS | 2004年 / 36卷 / 10期

关键词：

D O I：

10.1038/ng1431

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The enzyme glutamate dehydrogenase (GDH) is important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission. Human GDH exists in housekeeping and brain-specific isotypes encoded by the genes GLUD1 and GLUD2, respectively. Here we show that GLUD2 originated by retroposition from GLUD1 in the hominoid ancestor less than 23 million years ago. The amino acid changes responsible for the unique brain-specific properties of the enzyme derived from GLUD2 occurred during a period of positive selection after the duplication event.

引用

页码：1061 / 1063

页数：3

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