Regulation of the immune system by SOCS family adaptor proteins

被引：121

作者：

Ilangumaran, S

Ramanathan, S

Rottapel, R

机构：

[1] Univ Hlth Network, Princess Margaret Hosp, Ontario Canc Inst, Toronto, ON M5G 2M9, Canada

[2] Univ Sherbrooke, Div Immunol, Fac Med, Sherbrooke, PQ J1H 5N4, Canada

[3] Univ Toronto, Dept Med, Toronto, ON M5S 1A8, Canada

[4] Univ Toronto, Dept Immunol, Toronto, ON M5S 1A8, Canada

[5] Univ Toronto, Dept Med Biophys, Toronto, ON M5S 1A8, Canada

[6] St Michaels Hosp, Toronto, ON M5B 1W8, Canada

来源：

SEMINARS IN IMMUNOLOGY | 2004年 / 16卷 / 06期

基金：

加拿大健康研究院;

关键词：

cytokines; JAK-STAT pathway; SOCS; T cell homeostasis; inflammation;

D O I：

10.1016/j.smim.2004.08.015

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Signal transduction via cytokine receptors is regulated by several mechanisms that control initiation, magnitude and duration of the signaling pathways. Cytokine-induced SOCS family adaptors function as feedback inhibitors of cytokine receptor signaling by inhibiting the JAK-STAT signal transduction pathway. Specific gene-targeted mice have unveiled critical, non-overlapping functions for SOCS1 and SOCS3 in lymphocyte development and homeostasis, and in the regulation of macrophage and dendritic cell functions. In this review, we will discuss the structure of SOCS proteins, mechanisms by which they control the JAK-STAT pathway and their role in immune regulation. (C) 2004 Elsevier Ltd. All rights reserved.

引用

收藏

页码：351 / 365

页数：15

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