Valganciclovir for congenital CMV infection: A pilot study on plasma concentration in newborns and infants

被引：28

作者：

Galli, Luisa

Novelli, Andrea

Chiappini, Elena

Gervaso, Paola

Cassetta, Maria Iris

Fallani, Stefania

de Martino, Maurizio ^{[1
]}

机构：

[1] Univ Florence, Dept Pediat, Florence, Italy

[2] Univ Florence, Dept Pharmacol, Florence, Italy

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2007年 / 26卷 / 05期

关键词：

valganciclovir; newborns; pharmacokinetics; congenital; CMV;

D O I：

10.1097/01.inf.0000261111.90075.4d

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

The pharmacokinetics of valganciclovir were studied in 8 infants ranging in age from 4 to 90 days (mean 20 days). We suggest that doses of 15 mg/hg given twice daily may be suitable for neonates and young infants.

引用

页码：451 / 453

页数：3

共 10 条

[1]

Valganciclovir is safe and effective as pre-emptive therapy for CMV infection in allogeneic hematopoietic stem cell transplantation [J].

Ayala, E ;

Greene, J ;

Sandin, R ;

Perkins, J ;

Field, T ;

Tate, C ;

Fields, KK ;

Goldstein, S .

BONE MARROW TRANSPLANTATION, 2006, 37 (09) :851-856

[2]

Oral valganciclovir in children: single dose pharmacokinetics in a six-year-old girl [J].

Burri, M ;

Wiltshire, H ;

Kahlert, C ;

Wouters, G ;

Rudin, C .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2004, 23 (03) :263-266

[3]

Treatment of symptomatic congenital cytomegalovirus infection with valganciclovir [J].

Jansen, CFM ;

Toet, MC ;

Rademaker, CMA ;

Ververs, TFF ;

Gerards, LJ ;

van Loon, AM .

JOURNAL OF PERINATAL MEDICINE, 2005, 33 (04) :364-366

[4]

Effect of ganciclovir therapy on hearing in symptomatic congenital cytomegalovirus disease involving the central nervous system:: A randomized, controlled trial [J].

Kimberlin, DW ;

Lin, CY ;

Sánchez, PJ ;

Demmler, GJ ;

Dankner, W ;

Shelton, M ;

Jacobs, RF ;

Vaudry, W ;

Pass, RF ;

Kiell, JM ;

Soong, SJ ;

Whitley, RJ .

JOURNAL OF PEDIATRICS, 2003, 143 (01) :16-25

[5]

Separation methods for acyclovir and related antiviral compounds [J].

Loregian, A ;

Gatti, R ;

Palù, G ;

De Palo, EF .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2001, 764 (1-2) :289-311

[6]

A controlled trial of valganciclovir as induction therapy for cytomegalovirus retinitis. [J].

Martin, DF ;

Sierra-Madero, J ;

Walmsley, S ;

Wolitz, RA ;

Macey, K ;

Georgiou, P ;

Robinson, CA ;

Stempien, MJ .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (15) :1119-1126

[7]

Treatment of children with congenital cytomegalovirus infection with ganciclovir [J].

Michaels, MG ;

Greenberg, DP ;

Sabo, DL ;

Wald, ER .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2003, 22 (06) :504-508

[8]

Valganciclovir for treatment of congenital cytomegalovirus infection [J].

Schulzke, Sven ;

Buehrer, Christoph .

EUROPEAN JOURNAL OF PEDIATRICS, 2006, 165 (08) :575-576

[9]

Ganciclovir therapy for congenital cytomegalovirus infection in six infants [J].

Tanaka-Kitajima, N ;

Sugaya, N ;

Futatani, T ;

Kanegane, H ;

Suzuki, C ;

Oshiro, M ;

Hayakawa, M ;

Futamura, M ;

Morishima, T ;

Kimura, H .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2005, 24 (09) :782-785

[10]

Ganciclovir treatment of symptomatic congenital cytomegalovirus infection: Results of a phase II study [J].

Whitley, RJ ;

Cloud, G ;

Gruber, W ;

Storch, GA ;

Demmler, GJ ;

Jacobs, RF ;

Dankner, W ;

Spector, SA ;

Starr, S ;

Pass, RF ;

Stagno, S ;

Britt, WJ ;

Alford, C ;

Soong, SJ ;

Zhou, XJ ;

Sherrill, L ;

FitzGerald, JM ;

Sommadossi, JP .

JOURNAL OF INFECTIOUS DISEASES, 1997, 175 (05) :1080-1086

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