Transition metal catalysed cross-coupling between benzylic halides and aryl nucleophiles. Synthesis of some toxicologically interesting tetrachlorobenzyltoluenes.

被引：37

作者：

de Lang, RJ

van Hooijdonk, MJCM

Brandsma, L

Kramer, H

Seinen, W

机构：

[1] Univ Utrecht, Dept Preparat Organ Chem, NL-3584 CH Utrecht, Netherlands

[2] Univ Utrecht, Toxicol Res Inst, NL-3508 TD Utrecht, Netherlands

来源：

TETRAHEDRON | 1998年 / 54卷 / 12期

关键词：

D O I：

10.1016/S0040-4020(98)83030-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The aryl-benzyl cross-coupling in the presence of copper-, nickel-and palladium-catalysts has been investigated with a number of chlorine-and methyl-substituted arylmetal compounds ArM (M= MgBr, ZnCl) and (substituted) benzylic halides ArCH2X. The results have been applied in the selective synthesis of some toxicologically interesting tetrachlorobenzyltoluenes. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：2953 / 2966

页数：14

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