Neuromagnetic imaging of movement-related cortical oscillations in children and adults: Age predicts post-movement beta rebound

被引:160
作者
Gaetz, W. [1 ]
MacDonald, M. [2 ]
Cheyne, D. [2 ,3 ]
Snead, O. C. [4 ]
机构
[1] Childrens Hosp Philadelphia, Dept Radiol, Philadelphia, PA 19104 USA
[2] Hosp Sick Children, Dept Diagnost Imaging, Toronto, ON M5G 1X8, Canada
[3] Hosp Sick Children, Program Neurosci & Mental Hlth, Toronto, ON M5G 1X8, Canada
[4] Hosp Sick Children, Div Neurol, Toronto, ON M5G 1X8, Canada
关键词
Magnetoencephalography (MEG); Cortical oscillations; Event-related desynchronization (ERD); Event-related synchronization (ERS); Movement-related gamma synchrony (MRGS); Post-movement beta rebound (PMBR); GABAergic inhibition; PRIMARY MOTOR CORTEX; TRANSCRANIAL MAGNETIC STIMULATION; POSITRON-EMISSION-TOMOGRAPHY; HUMAN SENSORIMOTOR-CORTEX; GAMMA-AMINOBUTYRIC-ACID; SELF-PACED MOVEMENTS; FREELY MOVING RATS; INTRACORTICAL INHIBITION; ACETYLCHOLINE-RELEASE; DEVELOPMENTAL-CHANGES;
D O I
10.1016/j.neuroimage.2010.01.077
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We measured visually-cued motor responses in two developmentally separate groups of children and compared these responses to a group of adults. We hypothesized that if post-movement beta rebound (PMBR) depends on developmentally sensitive processes, PMBR will be greatest in adults and progressively decrease in children performing a basic motor task as a function of age. Twenty children (10 young children 4-6 years; 10 adolescent children 11-13 years) and 10 adults all had MEG recorded during separate recordings of right and left index finger movements. Beta band (15-30 Hz) event-related desynchronization (ERD) of bi-lateral sensorimotor areas was observed to increase significantly from both contralateral and ipsilateral MI with age. Movement-related gamma synchrony (60-90 Hz) was also observed from contralateral MI for each age group. However, PMBR was significantly reduced in the 4-6 year group and, while more prominent, remained significantly diminished in the adolescent (11-13 year) age group as compared to adults. PMBR measures were weak or absent in the youngest children tested and appear maximally from bilateral MI in adults. Thus PMBR may reflect an age-dependent inhibitory process of the primary motor cortex which comes on-line with normal development. Previous studies have shown PMBR may be observed from MI following a variety of movement-related tasks in adult participants - however, the origin and purpose of the PMBR is unclear. The current study shows that the expected PMBR from MI observed from adults is increasingly diminished in adolescent and young children respectively. A reduction in PMBR from children may reflect reduced motor cortical inhibition. Relatively less motor inhibition may facilitate neuronal plasticity and promote motor learning in children. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码:792 / 807
页数:16
相关论文
共 92 条
[1]   Alpha and beta oscillatory changes during stimulus-induced movement paradigms: effect of stimulus predictability [J].
Alegre, M ;
Gurtubay, IG ;
Labarga, A ;
Iriarte, J ;
Malanda, A ;
Artieda, J .
NEUROREPORT, 2003, 14 (03) :381-385
[2]   Beta electroencephalograph changes during passive movements: sensory afferences contribute to beta event-related desynchronization in humans [J].
Alegre, M ;
Labarga, A ;
Gurtubay, IG ;
Iriarte, J ;
Malanda, A ;
Artieda, J .
NEUROSCIENCE LETTERS, 2002, 331 (01) :29-32
[3]  
[Anonymous], 1967, Regional Development of the Brain in Early Life
[4]   THE PATTERNS AND SYNAPTIC PROPERTIES OF HORIZONTAL INTRACORTICAL CONNECTIONS IN THE RAT MOTOR CORTEX [J].
ARONIADOU, VA ;
KELLER, A .
JOURNAL OF NEUROPHYSIOLOGY, 1993, 70 (04) :1553-1569
[5]   Human cortical electroencephalography (EEG) rhythms during the observation of simple aimless movements: A high-resolution EEG study [J].
Babiloni, C ;
Babiloni, F ;
Carducci, F ;
Cincotti, F ;
Cocozza, G ;
Del Percio, C ;
Moretti, DV ;
Rossini, PM .
NEUROIMAGE, 2002, 17 (02) :559-572
[6]   The effect of diazepam on motor cortical oscillations and corticomuscular coherence studied in man [J].
Baker, MR ;
Baker, SN .
JOURNAL OF PHYSIOLOGY-LONDON, 2003, 546 (03) :931-942
[7]   BENIGN EPILEPSY OF CHILDREN WITH ROLANDIC (CENTRO-TEMPORAL) PAROXYSMAL FOCI - CLINICAL ENTITY - STUDY OF 221 CASES [J].
BEAUSSART, M .
EPILEPSIA, 1972, 13 (06) :795-811
[8]   EVOLUTION OF EPILEPSY WITH ROLANDIC PAROXYSMAL FOCI - STUDY OF 324 CASES [J].
BEAUSSART, M ;
FAOU, R .
EPILEPSIA, 1978, 19 (04) :337-342
[9]  
BENARI Y, 1994, PROG BRAIN RES, V102, P261
[10]   Antiepileptic drugs, learning, and behavior in childhood epilepsy [J].
Bourgeois, BFD .
EPILEPSIA, 1998, 39 (09) :913-921