Plasma hemopexin activity in pregnancy and preeclampsia

被引:39
作者
Bakker, Winston W.
Donker, Rogier B.
Timmer, Albertus
van Pampus, Marielle G.
van Son, Willem J.
Aarnoudse, Jan G.
van Goor, Harry
Niezen-Koning, Klary E.
Navis, Gerjan
Borghuis, Theo
Jongman, Rianne M.
Faas, Marijke M.
机构
[1] Univ Groningen, Dept Pathol & Lab Med, Med Ctr, Div Med Biol, NL-9700 RB Groningen, Netherlands
[2] Univ Groningen, Dept Obstet & Gynecol, Med Ctr, NL-9700 RB Groningen, Netherlands
[3] Univ Groningen, Dept Internal Med, Med Ctr, NL-9700 RB Groningen, Netherlands
[4] Univ Groningen, Dept Pediat, Med Ctr, NL-9700 RB Groningen, Netherlands
关键词
hemopexin; pregnancy; preeclampsia;
D O I
10.1080/10641950701274896
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: Plasma hemopexin activity, associated with increased vascular permeability, was evaluated in healthy pregnant and non-pregnant women and in pre-eclamptic women. Methods: Hemopexin activity and the hemopexin inhibitor, extracellular ATP, were assayed in plasma from pregnant (n=10), preeclamptic (n=9), and non-pregnant women (n=10) using standard methods. Abdominal fascia tissue fragments from preeclamptic and pregnant women were immunohistochemically stained for vascular ectoapyrase or ecto-5'nucleotidase. Results: The data show significantly enhanced Hx activity exclusively in plasma from pregnant women and significantly enhanced plasma ATP in pre-eclamptic women compared with the other groups. Dephosphorylation of preeclamptic plasma resulted in reactivation of Hx activity. Fascia tissue-samples from preeclamptic women showed reduced ecto-apyrase activity and enhanced ecto-5'nucleotidase activity compared to pregnant women. Conclusion: Enhanced hemopexin activity may be associated with normal pregnancy, but not with preeclampsia. Decreased hemopexin in pre-eclamptic patients may be due to enhanced plasma ATP, which is possibly promoted by diminished activity of vascular ecto-apyrase.
引用
收藏
页码:227 / 239
页数:13
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