Notch Signaling in the Immune System

被引：486

作者：

Radtke, Freddy ^{[1
]}

Fasnacht, Nicolas ^{[1
]}

MacDonald, H. Robson ^{[2
]}

机构：

[1] Ecole Polytech Fed Lausanne, Swiss Inst Expt Canc Res, CH-1015 Lausanne, Switzerland

[2] Univ Lausanne, Lausanne Branch, Ludwig Inst Canc Res, CH-1066 Epalinges, Switzerland

来源：

IMMUNITY | 2010年 / 32卷 / 01期

基金：

瑞士国家科学基金会;

关键词：

HEMATOPOIETIC STEM-CELLS; ACUTE LYMPHOBLASTIC-LEUKEMIA; GAMMA-SECRETASE INHIBITORS; REGULATORY T-CELLS; NF-KAPPA-B; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; DELTA-LIKE; IN-VIVO; DENDRITIC CELLS; LINEAGE COMMITMENT;

D O I：

10.1016/j.immuni.2010.01.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The Notch signaling pathway regulates many aspects of embryonic development, as well as differentiation processes and tissue homeostasis in multiple adult organ systems. Disregulation of Notch signaling is associated with several human disorders, including cancer. In the last decade, it became evident that Notch signaling plays important roles within the hematopoietic and immune systems. Notch plays an essential role in the development of embryonic hematopoietic stem cells and influences multiple lineage decisions of developing lymphoid and myeloid cells. Moreover, recent evidence suggests that Notch is an important modulator of T cell-mediated immune responses. In this review, we discuss Notch signaling in hematopoiesis, lymphocyte development, and function as well as in T cell acute lymphoblastic leukemia.

引用

页码：14 / 27

页数：14

共 127 条

[81] Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo [J].

Oyama, Toshinao ;

Harigaya, Kenichi ;

Muradil, Ablimit ;

Hozumi, Katsuto ;

Habu, Sonoko ;

Oguro, Hideyuki ;

Iwama, Atsushi ;

Matsuno, Kenji ;

Sakamoto, Reiko ;

Sato, Mitsuharu ;

Yoshida, Nobuaki ;

Kitagawa, Motoo .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (23) :9764-9769

[82] TCR-mediated Notch signaling regulates proliferation and IFN-γ production in peripheral T cells [J].

Palaga, T ;

Miele, L ;

Golde, TE ;

Osborne, BA .

JOURNAL OF IMMUNOLOGY, 2003, 171 (06) :3019-3024

[83] Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia [J].

Palomero, Teresa ;

Sulis, Maria Luisa ;

Cortina, Maria ;

Real, Pedro J. ;

Barnes, Kelly ;

Ciofani, Maria ;

Caparros, Esther ;

Buteau, Jean ;

Brown, Kristy ;

Perkins, Sherrie L. ;

Bhagat, Govind ;

Agarwal, Archana M. ;

Basso, Giuseppe ;

Castillo, Mireia ;

Nagase, Satoru ;

Cordon-Cardo, Carlos ;

Parsons, Ramon ;

Zuniga-Pflucker, Juan Carlos ;

Dominguez, Maria ;

Ferrando, Adolfo A. .

NATURE MEDICINE, 2007, 13 (10) :1203-1210

[84] NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth [J].

Palomero, Teresa ;

Lim, Wei Keat ;

Odom, Duncan T. ;

Sulis, Maria Luisa ;

Real, Pedro J. ;

Margolin, Adam ;

Barnes, Kelly C. ;

O'Neil, Jennifer ;

Neuberg, Donna ;

Weng, Andrew P. ;

Aster, Jon C. ;

Sigaux, Francois ;

Soulier, Jean ;

Look, A. Thomas ;

Young, Richard A. ;

Califano, Andrea ;

Ferrando, Adolfo A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (48) :18261-18266

[85] Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles [J].

Pear, WS ;

Aster, JC ;

Scott, ML ;

Hasserjian, RP ;

Soffer, B ;

Sklar, J ;

Baltimore, D .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 183 (05) :2283-2291

[86] The follicular versus marginal zone B lymphocyte cell fate decision [J].

Pillai, Shiv ;

Cariappa, Annaiah .

NATURE REVIEWS IMMUNOLOGY, 2009, 9 (11) :767-777

[87] Modulating Notch signaling by pathway-intrinsic and pathway-extrinsic mechanisms [J].

Poellinger, Lorenz ;

Lendahl, Urban .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2008, 18 (05) :449-454

[88] Notch1 expression in early lymphopoiesis influences B versus T lineage determination [J].

Pui, JC ;

Allman, D ;

Xu, LW ;

DeRocco, S ;

Karnell, FG ;

Bakkour, S ;

Lee, JY ;

Kadesch, T ;

Hardy, RR ;

Aster, JC ;

Pear, WS .

IMMUNITY, 1999, 11 (03) :299-308

[89] Deficient T cell fate specification in mice with an induced inactivation of Notch1 [J].

Radtke, F ;

Wilson, A ;

Stark, G ;

Bauer, M ;

van Meerwijk, J ;

MacDonald, HR ;

Aguet, M .

IMMUNITY, 1999, 10 (05) :547-558

[90] Direct induction of T lymphocyte-specific gene expression by the mammalian Notch signaling pathway [J].

Reizis, B ;

Leder, P .

GENES & DEVELOPMENT, 2002, 16 (03) :295-300

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