A major zebrafish polymorphism resource for genetic mapping

被引：28

作者：

Bradley, Kevin M.

Elmore, J. Bradford

Breyer, Joan P.

Yaspan, Brian L.

Jessen, Jason R.

Knapik, Ela W.

Smith, Jeffrey R.

机构：

[1] Vanderbilt Univ, Sch Med, Dept Med, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Sch Med, Dept Canc Biol, Nashville, TN 37232 USA

[3] Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Nashville, TN 37232 USA

[4] VA Tennessee Valley Healthcare Syst, Med Res Serv, Nashville, TN 37212 USA

来源：

GENOME BIOLOGY | 2007年 / 8卷 / 04期

关键词：

D O I：

10.1186/gb-2007-8-4-r55

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have identified 645,088 candidate polymorphisms in zebrafish and observe a single nucleotide polymorphism ( SNP) validation rate of 71% to 86%, improving with polymorphism confidence score. Variant sites are non-random, with an excess of specific novel T- and A-rich motifs. We positioned half of the polymorphisms on zebrafish genetic and physical maps as a resource for positional cloning. We further demonstrate bulked segregant analysis using the anchored SNPs as a method for high-throughput genetic mapping in zebrafish.

引用

页数：10

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