Resolution of DL-hydantoins by D-hydantoinase from Vigna angularis:: Production of highly enantioenriched N-carbamoyl-D-phenylglycine at 100% conversion

被引：28

作者：

Arcuri, MB ^{[1
]}

Antunes, OAC ^{[1
]}

Sabino, SJ ^{[1
]}

Pinto, GF ^{[1
]}

Oestreicher, EG ^{[1
]}

机构：

[1] Univ Fed Rio de Janeiro, Inst Quim, Ctr Tecnol, BR-21941945 Rio De Janeiro, Brazil

来源：

AMINO ACIDS | 2000年 / 19卷 / 02期

关键词：

amino acids; D-hydantoinase; N-carbamoyl-D-phenylglycine; substrate specificity; Vigna angularis;

D O I：

10.1007/s007260070025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

D-Hydantoinase from Vigna angularis hydrolyzed rac-5-monosubstituted-hydantoins with polar and aromatic side chains and dihydrothymine but rac-5,5-disubstituted-hydantoins were not substrates of this enzyme. 5-Phenylhydantoin was the best substrate. By using this substrate, N-carbamoyl-D-phenylglycine was obtained in quantitative yield and over 98% ee.

引用

页码：477 / 482

页数：6

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