Antibacterial activities and inhibitory effects of sitafloxacin (DU-6859a) and its optical isomers against type II topoisomerases

被引：36

作者：

Akasaka, T ^{[1
]}

Kurosaka, S ^{[1
]}

Uchida, Y ^{[1
]}

Tanaka, M ^{[1
]}

Sato, K ^{[1
]}

Hayakawa, I ^{[1
]}

机构：

[1] Daiichi Pharmaceut Co Ltd, New Prod Res Labs 1, Edogawa Ku, Tokyo 1348630, Japan

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1998年 / 42卷 / 05期

关键词：

D O I：

10.1128/AAC.42.5.1284

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The in vitro inhibitory effects of sitafloxacin (DU-6859a) and its three stereoisomers on bacterial DNA gyrase from Escherichia coli, topoisomerase IV from Staphylococcus aureus and topoisomerase II from human placenta were compared. No correlation was observed between the inhibitory activities of quinolones against bacterial type II topoisomerases and those against human topoisomerase II. Sitafloxacin showed the most potent inhibitory activities against bacterial type LI topoisomerases and the lowest activity against human type II topoisomerase.

引用

页码：1284 / 1287

页数：4

共 31 条

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