Dominance of the 'nondominant' hemisphere in depression

被引:46
作者
Okada, F
Takahashi, N
Tokumitsu, Y
机构
[1] HLTH SCI UNIV HOKKAIDO, DEPT CLIN PSYCHOL, ISHIKARI, HOKKAIDO, JAPAN
[2] HOKKAIDO UNIV, FAC PHARMACEUT SCI, DEPT PHARMACOL, SAPPORO, HOKKAIDO 060, JAPAN
关键词
depression; near-IR spectrophotometry; oxygenation; hemodynamics; nondominant hemisphere;
D O I
10.1016/0165-0327(95)00040-2
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We examined 36 patients with major depression diagnosed by DSM-III-R to find and qualify disturbances in brain oxygenation and hemodynamics during a psychological task. A group of 36 age- and sex-matched healthy volunteers were monitored as controls. Multichannel near-IR spectrophotometry (NIRS) was used to observe real-time alterations in the oxygenation in corresponding areas of the hemispheres at the forehead during the mirror drawing task (MDT). Nearly half of the patients (12 of 24 males and 4 of 12 females) showed a 'nondominant hemisphere response pattern', which was never observed in normal volunteers during the MDT. The other half of the patients showed a 'bilateral response pattern', There was no 'dominant hemisphere response pattern', the pattern observed in most normal males. When re-examined after recovery from depression, the response pattern of the two patients who had shown the 'nondominant hemisphere response pattern' during the course of the illness had changed to the 'bilateral response pattern'. The response pattern of the three patients with refractory depression who first showed the 'bilateral response pattern' changed to the 'nondominant response pattern' after several months. The nominally 'nondominant' hemisphere may become dominant during the course of depression.
引用
收藏
页码:13 / 21
页数:9
相关论文
共 32 条
[1]   BINOMIAL DISTRIBUTION OF RIGHT MIXED AND LEFT HANDEDNESS [J].
ANNETT, M .
QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY, 1967, 19 :327-&
[2]  
[Anonymous], 1987, DIAGNOSTIC STAT MANU, V4th
[3]  
BAXTER LR, 1985, ARCH GEN PSYCHIAT, V42, P441
[4]  
BAXTER LR, 1989, ARCH GEN PSYCHIAT, V46, P243
[5]   REGIONAL CEREBRAL BLOOD-FLOW IN AFFECTIVE-DISORDER [J].
BOLWIG, TG .
ACTA PSYCHIATRICA SCANDINAVICA, 1993, 87 :48-53
[6]  
BRAZY JE, 1985, PEDIATRICS, V75, P217
[7]   NEAR-INFRARED SPECTROSCOPY [J].
BRAZY, JE .
CLINICS IN PERINATOLOGY, 1991, 18 (03) :519-534
[8]  
CAIRNS CB, 1985, SURG GYNECOL OBSTET, V161, P145
[9]   REGIONAL CEREBRAL BLOOD-FLOW ABNORMALITIES IN DEPRESSED-PATIENTS WITH COGNITIVE IMPAIRMENT [J].
DOLAN, RJ ;
BENCH, CJ ;
BROWN, RG ;
SCOTT, LC ;
FRISTON, KJ ;
FRACKOWIAK, RSJ .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1992, 55 (09) :768-773
[10]  
DREVETS WC, 1992, J NEUROSCI, V12, P3628