Selective inhibition of low affinity IgE receptor (CD23) processing

被引：14

作者：

Bailey, S

Bolognese, B

Buckle, DR

Faller, A

Jackson, S

Louis-Flamberg, P

McCord, M

Mayer, RJ

Marshall, LA

Smith, DG

机构：

[1] SmithKline Beecham Pharmaceut, Harlow CM19 5AW, Essex, England

[2] SmithKline Beecham Pharmaceut, Epsom KT18 5XQ, Surrey, England

[3] SmithKline Beecham Pharmaceut, King Of Prussia, PA 19402 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(97)10149-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of hydroxamic acids related to the non-selective matrix metalloproteinase inhibitor Batimastat has been prepared, some members of which are potent inhibitors of the processing of the low affinity IgE receptor (CD 23). Increased activity is obtained by appropriate substitution at the a-position, whilst selectivity is gained by use of a P1' benzyl group in conjunction with a C-terminal primary amide. (C) 1997 Elsevier Science Ltd. All rights reserved.

引用

页码：29 / 34

页数：6

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