Reaction of COTC with glutathione: structure of the putative glyoxalase I inhibitor

被引：43

作者：

Huntley, CFM

Hamilton, DS

Creighton, DJ

Ganem, B ^{[1
]}

机构：

[1] Cornell Univ, Baker Lab, Dept Chem & Chem Biol, Ithaca, NY 14853 USA

[2] Univ Maryland, Dept Chem & Biochem, Baltimore, MD 21228 USA

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 20期

关键词：

D O I：

10.1021/ol006341z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The structure of the active glyoxalase I inhibitor derived from the Streptomyces griseosporeos metabolite COTC 1 has been conclusively identified by means of total synthesis as 2c, Human glyoxalase I is competitively inhibited by 2c (K-i = 183 +/- 6 mu M) but is not inhibited by 1 itself.

引用

页码：3143 / 3144

页数：2

共 13 条

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