Circadian rhythms in microorganisms: New complexities

被引:64
作者
Lakin-Thomas, PL
Brody, S
机构
[1] York Univ, Dept Biol, N York, ON M3J 1P3, Canada
[2] Univ Calif San Diego, Div Biol Sci, La Jolla, CA 92093 USA
关键词
clocks; fungi; Neurospora; Gonyaulax; Synechococcus;
D O I
10.1146/annurev.micro.58.030603.123744
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Recent advances in understanding circadian (daily) rhythms in the genera Neurospora, Gonyaulax, and Synechococcus are reviewed and new complexities in their circadian systems are described. The previous model, consisting of a unidirectional flow of information from input to oscillator to output, has now expanded to include multiple input pathways, multiple oscillators, multiple outputs; and feedback from oscillator to input and output to oscillator. New posttranscriptional features of the frq/white-collar oscillator (FWC) of Neurospora are described, including protein phosphorylation and degradation, dimerization, and complex formation. Experimental evidence is presented for frq-less oscillator(s) (FLO) downstream of the FWC. Mathematical models of the Neurospora system are also discussed.
引用
收藏
页码:489 / 519
页数:31
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