In or out? The dynamics of Smad nucleocytoplasmic shuttling

被引：61

作者：

Reguly, T ^{[1
]}

Wrana, JL ^{[1
]}

机构：

[1] Univ Toronto, Mt Sinai Hosp, Samuel Lunenfeld Res Inst,Program Mol Biol & Canc, Dept Med Genet & Microbiol, Toronto, ON M5G 1X5, Canada

来源：

TRENDS IN CELL BIOLOGY | 2003年 / 13卷 / 05期

关键词：

D O I：

10.1016/S0962-8924(03)00075-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Members of the TGF-beta family of growth factors mediate their effects through activation of intracellular Smad proteins, which form transcriptionally competent complexes that accumulate in the nucleus. Recently, several reports have demonstrated that Smads actively shuttle between the cytoplasm and nucleus by distinct mechanisms. Here, we summarize what is known about the dynamics of Smad localization and suggest reasons why nucleocytoplasmic shuttling might be important for proper signal transduction.

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页码：216 / 220

页数：5

相关论文

共 28 条

[1] Signal transduction by the TGF-β superfamily [J].

Attisano, L ;

Wrana, JL .

SCIENCE, 2002, 296 (5573) :1646-1647

[2] A novel mesoderm inducer, Madr2 functions in the activin signal transduction pathway [J].

Baker, JC ;

Harland, RM .

GENES & DEVELOPMENT, 1996, 10 (15) :1880-1889

[3] Microtubule binding to Smads may regulate TGFβ activity [J].

Dong, CM ;

Li, ZR ;

Alvarez, R ;

Feng, XH ;

Goldschmidt-Clermont, PJ .

MOLECULAR CELL, 2000, 5 (01) :27-34

[4]

GREEN JBA, 1990, NATURE, V347, P391, DOI 10.1038/347391a0

[5] The N domain of Smad7 is essential for specific inhibition of transforming growth factor-β signaling [J].

Hanyu, A ;

Ishidou, Y ;

Ebisawa, T ;

Shimanuki, T ;

Imamura, T ;

Miyazono, K .

JOURNAL OF CELL BIOLOGY, 2001, 155 (06) :1017-1027

[6] MADR1, a MAD-related protein that functions in BMP2 signaling pathways [J].

Hoodless, PA ;

Haerry, T ;

Abdollah, S ;

Stapleton, M ;

OConnor, MB ;

Attisano, L ;

Wrana, JL .

CELL, 1996, 85 (04) :489-500

[7] Dominant-negative Smad2 mutants inhibit activin/Vg1 signaling and disrupt axis formation in Xenopus [J].

Hoodless, PA ;

Tsukazaki, T ;

Nishimatsu, S ;

Attisano, L ;

Wrana, JL ;

Thomsen, GH .

DEVELOPMENTAL BIOLOGY, 1999, 207 (02) :364-379

[8] Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-β receptor activity [J].

Inman, GJ ;

Nicolás, FJ ;

Hill, CS .

MOLECULAR CELL, 2002, 10 (02) :283-294

[9] Transforming growth factor β1 induces nuclear export of inhibitory Smad7 [J].

Itoh, S ;

Landström, M ;

Hermansson, A ;

Itoh, F ;

Heldin, CH ;

Heldin, NE ;

ten Dijke, P .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (44) :29195-29201

[10] Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGFβ receptor for degradation [J].

Kavsak, P ;

Rasmussen, RK ;

Causing, CG ;

Bonni, S ;

Zhu, HT ;

Thomsen, GH ;

Wrana, JL .

MOLECULAR CELL, 2000, 6 (06) :1365-1375