Dissociation of locomotor and conditioned place preference responses following manipulation of GABA-A and AMPA receptors in ventral pallidum

被引：35

作者：

Gong, WH ^{[1
]}

Justice, JB ^{[1
]}

Neill, D ^{[1
]}

机构：

[1] EMORY UNIV, DEPT CHEM, ATLANTA, GA 30322 USA

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 1997年 / 21卷 / 05期

关键词：

AMPA; conditioned place preference; glutamate; GABA; locomotor activity; picrotoxin; reward; ventral pallidum;

D O I：

10.1016/S0278-5846(97)00084-5

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

1. This study examined the roles of GABAergic and glutamatergic neurotransmission in ventral pallidum (VP) in conditioned place preference and locomotor activity. 2. Picrotoxin(0.1 mu g), a GABA antagonist, and (+/-)alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA; 0.14 mu g), a non-NMDA glutamatergic agonist, were injected bilaterally into VP through implanted cannulae. 3. Both drugs produced a robust increase in locomotion, but neither produced conditioned place preference. 4. These results suggest a dissociation of locomotor activity and reward at the lever of ventral pallidum. In addition, it was argued that the GABAergic projection from nucleus accumbens to ventral pallidum may not be involved in the processing of reward initiated from dopaminergic activation in nucleus accumbens.

引用

页码：839 / 852

页数：14

共 36 条

[1] NEW PERSPECTIVES IN BASAL FOREBRAIN ORGANIZATION OF SPECIAL RELEVANCE FOR NEUROPSYCHIATRIC DISORDERS - THE STRIATOPALLIDAL, AMYGDALOID, AND CORTICOPETAL COMPONENTS OF SUBSTANTIA INNOMINATA [J].