Building Robust Transcriptomes with Master Splicing Factors

被引：120

作者：

Jangi, Mohini ^{[1
]}

Sharp, Phillip A. ^{[1
,2
]}

机构：

[1] MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA

[2] MIT, Dept Biol, Cambridge, MA 02139 USA

来源：

CELL | 2014年 / 159卷 / 03期

关键词：

NONSENSE-MEDIATED DECAY; MESSENGER-RNA DECAY; DOSAGE COMPENSATION GENE; BINDING-PROTEIN; SEX-DETERMINATION; CELL-DIFFERENTIATION; REGULATORY NETWORK; MAMMALIAN-TISSUES; POSITIVE FEEDBACK; SUPER-ENHANCERS;

D O I：

10.1016/j.cell.2014.09.054

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Coherent splicing networks arise from many discrete splicing decisions regulated in unison. Here, we examine the properties of robust, context-specific splicing networks. We propose that a subset of key splicing regulators, or "master splicing factors," respond to environmental cues to establish and maintain tissue transcriptomes during development.

引用

页码：487 / 498

页数：12

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