Probing the origins, diagnosis and treatment of amyloid diseases using antibodies

被引:38
作者
Dumoulin, M [1 ]
Dobson, CM [1 ]
机构
[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England
基金
英国惠康基金;
关键词
antibodies and antibody fragments; protein misfolding; protein aggregation; amyloid diseases; diagnostic and therapeutic strategies;
D O I
10.1016/j.biochi.2004.09.012
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The deposition of proteins in the form of amyloid fibrils is the characteristic feature of more than 20 medical conditions affecting the central nervous system or a variety of peripheral tissues. These disorders, which include Alzheimer's disease, the prion diseases and type II diabetes, are of enormous importance in the context of present-day human health and welfare. Extensive research is therefore being carried out to define the molecular details of the mechanism of the pathological conversion of amyloidogenic proteins from their soluble forms into fibrillar structures. This review focuses on recent studies that demonstrate the power of using antibodies or antibody fragments to probe the process of fibril formation, and discusses the emerging potential of these species as diagnostic and therapeutic agents. (C) 2004 Elsevier SAS. All rights reserved.
引用
收藏
页码:589 / 600
页数:12
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