Spinal cord injury in rat: treatment with bone marrow stromal cell transplantation

被引：466

作者：

Chopp, M

Zhang, XH

Li, Y

Wang, L

Chen, JL

Lu, DY

Lu, M

Rosenblum, M

机构：

[1] Henry Ford Hlth Sci Ctr, Dept Neurol, Detroit, MI 48202 USA

[2] Henry Ford Hlth Sci Ctr, Dept Neurosurg, Detroit, MI 48202 USA

[3] Henry Ford Hlth Sci Ctr, Dept Biostat, Detroit, MI 48202 USA

[4] Oakland Univ, Dept Phys, Rochester, MI USA

来源：

NEUROREPORT | 2000年 / 11卷 / 13期

关键词：

bone marrow stromal cell; rat; spinal cord injury; transplantation;

D O I：

10.1097/00001756-200009110-00035

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We tested the hypothesis that transplantation of bone marrow stromal cells (MSCs) into the spinal cord after a contusion injury promotes functional outcome. Rats (n=31) were subjected to a weight driven implant injury. MSCs or phosphate buffered saline was injected into the spinal cord 1 week after injury. Sections of tissue were analyzed by double-labeled immunohistochemistry for MSC identification. Functional outcome measurements using the Basso-Beattie-Bresnehan score were performed weekly to 5 weeks post-injury. The data indicate significant improvement in functional outcome in animals treated with MSC transplantation compared to control animals. Scattered cells derived from MSCs expressed neural protein markers. These data suggest that transplantation of MSCs may have a therapeutic role after spinal cord injury. NeuroReport 11:3001-3005 (C) 2000 Lippincott Williams & Wilkins.

引用

页码：3001 / 3005

页数：5

共 24 条

[1] Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats - similarities to astrocyte grafts [J].