Tubelactomicin A, a novel 16-membered lactone antibiotic, from Nocardia sp.: I.: Taxonomy, production, isolation and biological properties

被引：35

作者：

Igarashi, M ^{[1
]}

Hayashi, C ^{[1
]}

Homma, Y ^{[1
]}

Hattori, S ^{[1
]}

Kinoshita, N ^{[1
]}

Hamada, M ^{[1
]}

Takeuchi, T ^{[1
]}

机构：

[1] Inst Microbial Chem, Shinagawa Ku, Tokyo 1410021, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2000年 / 53卷 / 10期

关键词：

D O I：

10.7164/antibiotics.53.1096

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A novel 16-membered lactone antibiotic named tubelactomicin A was isolated from the culture broth of an actinomycete strain. The producing organism, designated MK703-102F1, was identified as a member of Nocardia. Tubelactomicin A was isolated from the culture broth; by Diaion HP20 absorption, ethyl acetate extraction, silica gel and Sephadex LH-20 column chromatographies and centrifugal liquid-liquid partition chromatography (CPC). Tubelactomicin A showed strong activity against acid-fast bacteria including the drug-resistant strains.

引用

页码：1096 / 1101

页数：6

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