Stereoselective synthesis of substituted N-heterocycles via sequential cross metathesis -: reductive cyclization

被引：31

作者：

Gebauer, J ^{[1
]}

Dewi, P ^{[1
]}

Blechert, S ^{[1
]}

机构：

[1] Tech Univ Berlin, Inst Chem, D-10623 Berlin, Germany

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 01期

关键词：

cross metathesis; reductive amination; ruthenium catalyst; indolizidines; pyrrolizidines;

D O I：

10.1016/j.tetlet.2004.11.030

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A diastereoselective synthesis of substituted mono- and bicyclic-piperidine and pyrrolidine derivatives is employing a highly selective cross metathesis (CM) reaction followed by a domino reduction-cyclization process. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：43 / 46

页数：4

共 35 条

[1]

[Anonymous], 1993, ALKALOIDS CHEM PHARM

[2]

Benetti S, 2002, SYNTHESIS-STUTTGART, P331

[3] Synthesis of 2,6-disubstituted piperidine-bearing α-amino acid side-chains [J].