Association study of the brain-derived neurotrophic factor (BDNF) gene with bipolar disorder

被引：123

作者：

Nakata, K

Ujike, H

Sakai, A

Uchida, N

Nomura, A

Imamura, T

Katsu, T

Tanaka, Y

Hamamura, T

Kuroda, S

机构：

[1] Okayama Univ, Grad Sch Med & Dent, Dept Neuropsychiat, Okayama 7008558, Japan

[2] Kasaoka Hosp, Kasaoka, Okayama 7140022, Japan

[3] Nishikawa Hosp, Hamada, Shimane 6970052, Japan

[4] Takaoka Hosp, Himeji, Hyogo 6700061, Japan

[5] Takahashi Hosp, Takahashi, Okayama 7160061, Japan

来源：

NEUROSCIENCE LETTERS | 2003年 / 337卷 / 01期

关键词：

brain-derived neurotrophic factor; bipolar disorder; polymorphism; association study;

D O I：

10.1016/S0304-3940(02)01292-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Brain-derived neurotrophic factor (BDNF) belongs to a family of neurotrophic factors and has been demonstrated to promote the survival, differentiation, and maintenance of a broad variety of central nervous system neurons. Several reports have suggested that the BDNF gene is a plausible functional candidate gene underlying the predisposition for developing bipolar disorder (BPD). In the present study, we investigated the possible role of the BDNF gene in the etiology of BPD using a matched case-control association design in a Japanese population. There was no evidence for an allelic or genotypic association of two polymorphisms (-1360C > T and 196G > A) of the BDNF gene with BPD. Furthermore, no significant association was observed between these polymorphisms and either of two diagnostic subtypes (bipolars I and II disorder). The results suggest that the BDNF gene is unlikely to confer susceptibility to BPD. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

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页码：17 / 20

页数：4

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