A computational analysis of whole-genome expression data reveals chromosomal domains of gene expression

被引：414

作者：

Cohen, BA ^{[1
]}

Mitra, RD ^{[1
]}

Hughes, JD ^{[1
]}

Church, GM ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

来源：

NATURE GENETICS | 2000年 / 26卷 / 02期

关键词：

D O I：

10.1038/79896

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Chromosome correlation maps display correlations between the expression patterns of genes on the same chromosome. Using these maps, we show here that adjacent pairs of genes, as well as nearby non-adjacent pairs of genes, show correlated expression independent of their orientation. We present specific examples of adjacent pairs with highly correlated expression patterns, in which the promoter of only one of the two genes contains an upstream activating sequence (UAS) known to be associated with that expression pattern. Finally, we show that genes with similar functions tend to occur in adjacent positions along the chromosomes. Our results suggest that, in certain chromosomal expression domains, an UAS can affect the transcription of genes that are not immediately downstream from it.

引用

页码：183 / 186

页数：4

共 17 条

[1] Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
Altschul, SF
Madden, TL
Schaffer, AA
Zhang, JH
Zhang, Z
Miller, W
Lipman, DJ
[J]. NUCLEIC ACIDS RESEARCH, 1997, 25 (17) : 3389 - 3402
[2] A genome-wide transcriptional analysis of the mitotic cell cycle
Cho, RJ
Campbell, MJ
Winzeler, EA
Steinmetz, L
Conway, A
Wodicka, L
Wolfsberg, TG
Gabrielian, AE
Landsman, D
Lockhart, DJ
Davis, RW
[J]. MOLECULAR CELL, 1998, 2 (01) : 65 - 73
[3] The transcriptional program of sporulation in budding yeast
Chu, S
DeRisi, J
Eisen, M
Mulholland, J
Botstein, D
Brown, PO
Herskowitz, I
[J]. SCIENCE, 1998, 282 (5389) : 699 - 705
[4] Chromatin unfolds
Felsenfeld, G
[J]. CELL, 1996, 86 (01) : 13 - 19
[5] In silico detection of control signals:: mRNA 3′-end-processing sequences in diverse species
Graber, JH
Cantor, CR
Mohr, SC
Smith, TF
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (24) : 14055 - 14060
[6] Computational identification of cis-regulatory elements associated with groups of functionally related genes in Saccharomyces cerevisiae
Hughes, JD
Estep, PW
Tavazoie, S
Church, GM
[J]. JOURNAL OF MOLECULAR BIOLOGY, 2000, 296 (05) : 1205 - 1214
[7] Switching transcription on and off during the yeast cell cycle: Cln/Cdc28 kinases activate bound transcription factor SBF (Swi4/Swi6) at Start, whereas Clb/Cdc28 kinases displace it from the promoter in G(2)
Koch, C
Schleiffer, A
Ammerer, G
Nasmyth, K
[J]. GENES & DEVELOPMENT, 1996, 10 (02) : 129 - 141
[8] THE DIVERGENTLY TRANSCRIBED GENES ENCODING YEAST RIBOSOMAL-PROTEINS L46 AND S24 ARE ACTIVATED BY SHARED RPG-BOXES
KRAAKMAN, LS
MAGER, WH
MAURER, KTC
NIEUWINT, RTM
PLANTA, RJ
[J]. NUCLEIC ACIDS RESEARCH, 1989, 17 (23) : 9693 - 9706
[9] MIPS:: a database for genomes and protein sequences
Mewes, HW
Frishman, D
Gruber, C
Geier, B
Haase, D
Kaps, A
Lemcke, K
Mannhaupt, G
Pfeiffer, F
Schüller, C
Stocker, S
Weil, B
[J]. NUCLEIC ACIDS RESEARCH, 2000, 28 (01) : 37 - 40
[10] Moore D. S., 1998, INTRO PRACTICE STAT

← 1 2 →