A tosyliminium ion-based total synthesis of (±)-schefferine

被引：11

作者：

Bianchi, DA

Kaufman, TS

机构：

[1] Univ Nacl Rosario, CONICET, Inst Quim Organ Sintesis, RA-2000 Rosario, Santa Fe, Argentina

[2] Univ Nacl Rosario, Fac Ciencias Bioquim & Farmaceut, RA-2000 Rosario, Santa Fe, Argentina

来源：

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE | 2000年 / 78卷 / 09期

关键词：

total synthesis; (+/-)-schefferine; natural product; tosyliminium ion; Mitsunobu amination;

D O I：

10.1139/cjc-78-9-1165

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthesis of the phenolic tetrahydroprotoberberine alkaloid (+/-)-schefferine is reported, featuring as key steps a tosyliminium ion-mediated Friedel-Crafts alkylation of eugenol dimethyl ether and an intramolecular Mitsunobu-type amination.

引用

页码：1165 / 1169

页数：5

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