20 years of gene therapy for SCID

被引：107

作者：

Fischer, Alain ^{[1
,2
,3
]}

Hacein-Bey-Abina, Salima ^{[1
,2
,4
]}

Cavazzana-Calvo, Marina ^{[1
,2
,4
]}

机构：

[1] INSERM, Paris, France

[2] Paris Descartes Univ, Paris, France

[3] Hop Necker Enfants Malad, AP HP, Unite Immunol & Hematol Pediat, Paris, France

[4] Hop Necker Enfants Malad, AP HP, Ctr Invest Clin Integre Biotherapies, Dept Biotherapy, Paris, France

来源：

NATURE IMMUNOLOGY | 2010年 / 11卷 / 06期

关键词：

SEVERE COMBINED IMMUNODEFICIENCY; LENTIVIRAL VECTOR; CANCER; DISEASE; TRIALS; RECONSTITUTION; LYMPHOCYTES; DEFICIENCY; DOUBTS; CELLS;

D O I：

10.1038/ni0610-457

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Severe combined immunodeficiency conditions are devastating disorders of adaptive immunity. Although these diseases were initially treated by transplantation of allogeneic hematopoietic stem cells, the past 20 years has shown that these conditions are correctable by gene therapy.

引用

页码：457 / 460

页数：4

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