Relaxin: a pregnancy hormone as central player of body fluid and circulation homeostasis

被引：35

作者：

Dschietzig, T ^{[1
]}

Stangl, K ^{[1
]}

机构：

[1] Univ Klinikum, Charite, Med Klin Schwerpunkt Kardiol Anagiol & Pulmol, D-10117 Berlin, Germany

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2003年 / 60卷 / 04期

关键词：

cAMP; G-protein receptor; MAP kinase; myocardium; nitric oxide; peptide; tyrosine kinase;

D O I：

10.1007/s00018-003-2169-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The peptide relaxin has long been regarded as an important hormone of pregnancy, contributing to changes in connective tissue composition as well as to regulation of implantation, myometrial activity and labor. On the other hand, the astonishing pleiotropy of this hormone escaped scientific awareness. This review focuses on new facets of relaxin, including its antifibrotic effects, its role in the control of pituitary hormone release, its vasodilator and pro-angiogenic properties and its versatile myocardial actions. Recent progress in understanding relaxin's receptor and signaling mechanisms is also highlighted. The peptide will be characterized as potential regulator of body fluid and circulation homeostasis.

引用

页码：688 / 700

页数：13

共 179 条

[1]

ADHAM IM, 1993, J BIOL CHEM, V268, P26668

[2]

ARMBRUSTER FP, 2000, P 3 INT C REL REL PE, P273

[3] RELAXIN GENE-EXPRESSION IN THE PORCINE FOLLICLE DURING PREOVULATORY DEVELOPMENT INDUCED BY GONADOTROPINS [J].

BAGNELL, CA ;

TSARK, W ;

TASHIMA, L ;

DOWNEY, BR ;

TSANG, BK ;

AINSWORTH, L .

JOURNAL OF MOLECULAR ENDOCRINOLOGY, 1990, 5 (03) :211-219

[4] Relaxin up-regulates the nitric oxide biosynthetic pathway in the mouse uterus: Involvement in the inhibition of myometrial contractility [J].

Bani, D ;

Baccari, MC ;

Nistri, S ;

Calamai, F ;

Bigazzi, M ;

Sacchi, TB .

ENDOCRINOLOGY, 1999, 140 (10) :4434-4441

[5] Relaxin activates the L-arginine nitric oxide pathway in vascular smooth muscle cells in culture [J].

Bani, D ;

Failli, P ;

Bello, MG ;

Thiemermann, C ;

Sacchi, TB ;

Bigazzi, M ;

Masini, E .

HYPERTENSION, 1998, 31 (06) :1240-1247

[6] Relaxin: A pleiotropic hormone [J].

Bani, D .

GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM, 1997, 28 (01) :13-22

[7]

BANI D, 1995, CANCER RES, V55, P5272

[8] RELAXIN REDUCES THE NUMBER OF CIRCULATING PLATELETS AND DEPRESSES PLATELET-RELEASE FROM MEGAKARYOCYTES - STUDIES IN RATS [J].

BANI, D ;

MAURIZI, M ;

BIGAZZI, M .

PLATELETS, 1995, 6 (06) :330-335

[9]

Bani D, 1997, B CANCER, V84, P179

[10] Relaxin counteracts asthma-like reaction induced by inhaled antigen in sensitized guinea pigs [J].

Bani, D ;

Ballati, L ;

Masini, E ;

Bigazzi, M ;

Sacchi, TB .

ENDOCRINOLOGY, 1997, 138 (05) :1909-1915

← 1 2 3 4 5 6 7 8 9 10 →